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Gene id 6256
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol RXRA   Gene   UCSC   Ensembl
Aliases NR2B1
Gene name retinoid X receptor alpha
Alternate names retinoic acid receptor RXR-alpha, nuclear receptor subfamily 2 group B member 1, retinoid X nuclear receptor alpha,
Gene location 9q34.2 (134326454: 134440585)     Exons: 12     NC_000003.12
Gene summary(Entrez) Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by bind
OMIM 180245

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa04151PI3K-Akt signaling pathway
hsa04659Th17 cell differentiation
hsa04920Adipocytokine signaling pathway
hsa03320PPAR signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04928Parathyroid hormone synthesis, secretion and action
hsa04976Bile secretion
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer
hsa05226Gastric cancer
hsa05216Thyroid cancer
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa04932Non-alcoholic fatty liver disease
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
hsa04928Parathyroid hormone synthesis, secretion and action
hsa05202Transcriptional misregulation in cancer
hsa04919Thyroid hormone signaling pathway
hsa04976Bile secretion
hsa04932Non-alcoholic fatty liver disease
hsa05223Non-small cell lung cancer
hsa05226Gastric cancer
hsa04659Th17 cell differentiation
hsa04920Adipocytokine signaling pathway
hsa05222Small cell lung cancer
hsa05160Hepatitis C
hsa03320PPAR signaling pathway
hsa05216Thyroid cancer

Diseases

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Associated diseases References
Cancer (renal cell) GAD: 19753122
Cancer (lung) GAD: 18676680
Cancer (prostate) GAD: 19255064
Adenoma GAD: 20145122
Cancer (bladder) GAD: 19692168
Cancer (colorectal) GAD: 20558521
Head and neck cancer GAD: 20819778
Atherosclerosis GAD: 17272748
Coronary heart disease GAD: 20855565
Coronary heart disease GAD: 20070029
Hypercholesterolemia GAD: 20602615
Alzheimer's disease GAD: 18544046
Schizophrenia GAD: 15635645
Infertility MIK: 24882558
Chronic obstructive pulmonary disease (COPD) GAD: 19625176
Chronic renal failure GAD: 21085059
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Cryptorchidism MIK: 28606200
Male infertility MIK: 24882558

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
24882558 Idiopathic
infertili
ty in IVF

Male infertility RXRA
DCXR
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract
28606200 Cryptorchi
dism
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
 Male infertility MeDIP-Seq
 Show abstract