• Gene id: 60560

Gene Summary

• Gene Symbol: NAA35   Gene   UCSC   Ensembl
• Aliases: EGAP, MAK10, MAK10P, bA379P1.1
• Gene name: N-alpha-acetyltransferase 35, NatC auxiliary subunit
• Alternate names: N-alpha-acetyltransferase 35, NatC auxiliary subunit, MAK10 homolog, amino-acid N-acetyltransferase subunit, corneal wound healing-related protein, embryonic growth-associated protein homolog, protein MAK10 homolog,
• Gene location: 9q21.33 (85941141: 86026354)     Exons: 26     NC_000009.12

Protein Summary

• Protein general information: Q5VZE5  
  • Name: N alpha acetyltransferase 35, NatC auxiliary subunit (Embryonic growth associated protein homolog) (Protein MAK10 homolog)
  • Length: 725  
  • Mass: 83639
• Sequence:

  MVMKASVDDDDSGWELSMPEKMEKSNTNWVDITQDFEEACRELKLGELLHDKLFGLFEAMSAIEMMDPKMDAGMI
  GNQVNRKVLNFEQAIKDGTIKIKDLTLPELIGIMDTCFCCLITWLEGHSLAQTVFTCLYIHNPDFIEDPAMKAFA
  LGILKICDIAREKVNKAAVFEEEDFQSMTYGFKMANSVTDLRVTGMLKDVEDDMQRRVKSTRSRQGEERDPEVEL
  EHQQCLAVFSRVKFTRVLLTVLIAFTKKETSAVAEAQKLMVQAADLLSAIHNSLHHGIQAQNDTTKGDHPIMMGF
  EPLVNQRLLPPTFPRYAKIIKREEMVNYFARLIDRIKTVCEVVNLTNLHCILDFFCEFSEQSPCVLSRSLLQTTF
  LVDNKKVFGTHLMQDMVKDALRSFVSPPVLSPKCYLYNNHQAKDCIDSFVTHCVRPFCSLIQIHGHNRARQRDKL
  GHILEEFATLQDEAEKVDAALHTMLLKQEPQRQHLACLGTWVLYHNLRIMIQYLLSGFELELYSMHEYYYIYWYL
  SEFLYAWLMSTLSRADGSQMAEERIMEEQQKGRSSKKTKKKKKVRPLSREITMSQAYQNMCAGMFKTMVAFDMDG
  KVRKPKFELDSEQVRYEHRFAPFNSVMTPPPVHYLQFKEMSDLNKYSPPPQSPELYVAASKHFQQAKMILENIPN
  PDHEVNRILKVAKPNFVVMKLLAGGHKKESKVPPEFDFSAHKYFPVVKLV

• Structural information:
  • Interpro: IPR007244  
  • STRING: ENSP00000354972
• Other Databases: GeneCards:  NAA35  Malacards:  NAA35

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004596	peptide alpha-N-acetyltransferase activity	IBA	molecular function
GO:0006474	N-terminal protein amino acid acetylation	IBA	biological process
GO:0031417	NatC complex	IBA	cellular component
GO:0031417	NatC complex	IDA	cellular component
GO:0005844	polysome	IDA	colocalizes with
GO:0005737	cytoplasm	IDA	cellular component
GO:0043066	negative regulation of apoptotic process	IMP	biological process
GO:0031417	NatC complex	IEA	cellular component
GO:0017196	N-terminal peptidyl-methionine acetylation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0048659	smooth muscle cell proliferation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	ISS	cellular component
GO:0048659	smooth muscle cell proliferation	ISS	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq