• Gene id: 59336

Gene Summary

• Gene Symbol: PRDM13   Gene   UCSC   Ensembl
• Aliases: MU-MB-20.220, PFM10
• Gene name: PR/SET domain 13
• Alternate names: PR domain zinc finger protein 13, PR domain 13, PR domain containing 13, PR-domain containing protein 13,
• Gene location: 6q16.2 (99606832: 99615561)     Exons: 4     NC_000006.12
• OMIM: 616741

Protein Summary

• Protein general information: Q9H4Q3  
  • Name: PR domain zinc finger protein 13 (EC 2.1.1. ) (PR domain containing protein 13)
  • Length: 707  
  • Mass: 73981
• Sequence:

  MHGAARAPATSVSADCCIPAGLRLGPVPGTFKLGKYLSDRREPGPKKKVRMVRGELVDESGGSPLEWIGLIRAAR
  NSQEQTLEAIADLPGGQIFYRALRDVQPGEELTVWYSNSLAQWFDIPTTATPTHDEKGEERYICWYCWRTFRYPN
  SLKAHLRFHCVFSGGGGGAFLHHEHAARQGAVPAADGLGLSPKPPAPDFAAPSQAGTLRPHPLGPPPVQACGARE
  GIKREASSAPSATSPTPGKWGQPKKGKEQLDRALDMSGAARGQGHFLGIVGGSSAGVGSLAFYPGVRSAFKPAGL
  ARAAAAAHGDPYREESSSKQGAGLALGRLLGGGRACGRPGSGENSAAGGAGHHHHHHAHHHHHPKCLLAGDPPPP
  PPPGLPCSGALRGFPLLSVPPEEASAFKHVERAPPAAAALPGARYAQLPPAPGLPLERCALPPLDPGGLKAYPGG
  ECSHLPAVMPAFTVYNGELLYGSPATTAYYPLKLHFGGLLKYPESISYFSGPAAAALSPAELGSLASIDREIAMH
  NQQLSEMAAGKGRGRLDSGTLPPAVAAAGGTGGGGSGGSGAGKPKTGHLCLYCGKLYSRKYGLKIHMRTHTGYKP
  LKCKVCLRPFGDPSNLNKHIRLHAEGNTPYRCEFCGKVLVRRRDLERHVKSRHPGQSLLAKAGDGPGAEPGYPPE
  PGDPKSDDSDVDVCFTDDQSDPEVGGGGERDL

• Structural information:
  • Protein Domains: (1..11-)
    (/note="SET-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00190"-)
  • Interpro: IPR001214  IPR036236  IPR013087  
  • Prosite: PS50280 PS00028 PS50157
  • STRING: ENSP00000358217
• Other Databases: GeneCards:  PRDM13  Malacards:  PRDM13

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042054	histone methyltransferase activity	IBA	molecular function
GO:0010468	regulation of gene expression	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0003677	DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0022008	neurogenesis	IEA	biological process
GO:0003682	chromatin binding	IEA	molecular function
GO:0001085	RNA polymerase II transcription factor binding	IEA	molecular function
GO:0042054	histone methyltransferase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0000122	negative regulation of transcription by RNA polymerase II	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0016571	histone methylation	IEA	biological process
GO:0016571	histone methylation	IEA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)