• Gene id: 5792

Gene Summary

• Gene Symbol: PTPRF   Gene   UCSC   Ensembl
• Aliases: BNAH2, LAR
• Gene name: protein tyrosine phosphatase receptor type F
• Alternate names: receptor-type tyrosine-protein phosphatase F, LCA-homolog, leukocyte antigen-related (LAR) PTP receptor, leukocyte antigen-related tyrosine phosphatase, leukocyte common antigen related, protein tyrosine phosphatase, receptor type, F polypeptide, receptor-linke,
• Gene location: 1p34.2 (43522237: 43623671)     Exons: 43     NC_000001.11
• Gene summary(Entrez): The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran
• OMIM: 179590

Protein Summary

• Protein general information: P10586  
  • Name: Receptor type tyrosine protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)
  • Length: 1907  
  • Mass: 212879
• Sequence:

  MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSS
  QRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKAR
  TATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYV
  RVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA
  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYS
  IGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVY
  YTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESD
  TRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR
  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLE
  KWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVR
  LENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPT
  MMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL
  GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTL
  TGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNG
  QSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQD
  PSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL
  GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILII
  LIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGL
  KFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQG
  PLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS
  SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVD
  IYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSK
  AHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWR
  MLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF
  TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLR
  TQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT

• Structural information:
  • Protein Domains: (33..12-)
    1 (/note="Ig-like-C2-type)
    (135..22-)
    2 (/note="Ig-like-C2-type)
    (232..31-)
    3 (/note="Ig-like-C2-type)
    (321..41-)
    1 (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316-)
    (416..51-)
    (/n-)
  • Interpro: IPR003961  IPR036116  IPR007110  IPR036179  IPR013783   IPR013098  IPR003599  IPR003598  IPR029021  IPR000242  IPR016130  IPR003595  IPR000387  
  • Prosite: PS50853 PS50835 PS00383 PS50056 PS50055
  • CDD: cd00063
  • PDB: 1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4
  • PDBsum: 1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4
  • STRING: ENSP00000353030
• Other Databases: GeneCards:  PTPRF  Malacards:  PTPRF

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0050839	cell adhesion molecule binding	IPI	molecular function
GO:0006470	protein dephosphorylation	IBA	biological process
GO:0004725	protein tyrosine phosphatase activity	IBA	molecular function
GO:0099560	synaptic membrane adhesion	IBA	biological process
GO:0035335	peptidyl-tyrosine dephosphorylation	IBA	biological process
GO:0004725	protein tyrosine phosphatase activity	IDA	molecular function
GO:0016477	cell migration	IMP	biological process
GO:0004725	protein tyrosine phosphatase activity	IMP	molecular function
GO:1900121	negative regulation of receptor binding	IMP	biological process
GO:0035335	peptidyl-tyrosine dephosphorylation	IMP	biological process
GO:0004725	protein tyrosine phosphatase activity	IEA	molecular function
GO:0006470	protein dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0016791	phosphatase activity	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0007155	cell adhesion	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0008201	heparin binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	TAS	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0007155	cell adhesion	TAS	biological process
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	TAS	biological process
GO:0004725	protein tyrosine phosphatase activity	IEA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0048679	regulation of axon regeneration	IEA	biological process
GO:0044877	protein-containing complex binding	IEA	molecular function
GO:0043025	neuronal cell body	IEA	cellular component
GO:0031102	neuron projection regeneration	IEA	biological process
GO:0043005	neuron projection	IEA	cellular component
GO:0035373	chondroitin sulfate proteoglycan binding	IEA	molecular function
GO:0010975	regulation of neuron projection development	IEA	biological process
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0099560	synaptic membrane adhesion	IMP	biological process
GO:0099560	synaptic membrane adhesion	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04910	Insulin signaling pathway
hsa04514	Cell adhesion molecules
hsa04931	Insulin resistance
hsa04520	Adherens junction

Diseases

Associated diseases	References
Hyperinsulinism	PMID:11309481
obesity	PMID:9218523
obesity	PMID:7769120
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq