• Gene id: 57718

Gene Summary

• Gene Symbol: PPP4R4   Gene   UCSC   Ensembl
• Aliases: CFAP14, KIAA1622, PP4R4
• Gene name: protein phosphatase 4 regulatory subunit 4
• Alternate names: serine/threonine-protein phosphatase 4 regulatory subunit 4, HEAT-like repeat-containing protein, cilia and flagella associated protein 14,
• Gene location: 14q32.12-q32.13 (94174311: 94279734)     Exons: 31     NC_000014.9
• Gene summary(Entrez): The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and app
• OMIM: 189980

Protein Summary

• Protein general information: Q6NUP7  
  • Name: Serine/threonine protein phosphatase 4 regulatory subunit 4
  • Length: 873  
  • Mass: 99452
• Sequence:

  MHPPPPAAAMDFSQNSLFGYMEDLQELTIIERPVRRSLKTPEEIERLTVDEDLSDIERAVYLLSAGQDVQGTSVI
  ANLPFLMRQNPTETLRRVLPKVREALHVAGVEMQLTAAMSFLTILQDESVSIHAYTHSFLQVILLHLEHRDTGVS
  NAWLETLLSVIEVLPKETLRHEILNPLVSKAQLSQTVQSRLVSCKILGKLTNKFDAHTIKREILPLVKSLCQDVE
  YEVRSCMCRQLENIAQGIGTELTKSVVLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDDRSQTILPLVKSFCE
  KSFKADESILISLSFHLGKLCHGLYGIFTPDQHLRFLEFYKKLCTLGLQQENGHNENQIPPQILEQEKKYISVRK
  NCAYNFPAMIVFVDPKNFHMELYSTFFCLCHDPEVPVRYTIAICFYEVSKLLNSGVYLIHKELITLLQDESLEVL
  DALIDHLPEILELMSTGGESSVQENKLSSLPDLIPALTAAEQRAAASLKWRTHEKLLQKYACLPHVISSDQIYYR
  FLQRMFTIMMTNNVLPVQKAASRTLCIFLRYNRKQEQRHEVIQKLIEQLGQGKSYWNRLRFLDTCEFIIEIFSKS
  FFCKYFFLPAIELTHDPVANVRMKLCYLLPKVKSTLKIPADKHLLQQLEMCVRKLLCQEKDKDVLAIVKRTVLEL
  DRMEMSMDAFQKKFYEKDLLDQEKEREELLLLEMEQLEKEKQQNDGRPMSDKMFEKKRRDTKTPTQSLPKNIPIS
  VPGPSSVTPSTSKEIKKSKLIRSQSFNNQAFHAKYGNLEKCASKSSTTGYTTSVSGLGKTSVLSLADDSFRTRNA
  SSVPSSFSPNTPLPSTSRGTGNSVDPKSSGSKDTQPRKATLKSRKSNP

• Structural information:
  • Interpro: IPR011989  IPR016024  IPR021133  IPR039918  
  • Prosite: PS50077
  • STRING: ENSP00000305924
• Other Databases: GeneCards:  PPP4R4  Malacards:  PPP4R4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0019888	protein phosphatase regulator activity	IBA	molecular function
GO:0032515	negative regulation of phosphoprotein phosphatase activity	IBA	biological process
GO:0080163	regulation of protein serine/threonine phosphatase activity	IBA	biological process
GO:0005829	cytosol	IBA	cellular component
GO:0008287	protein serine/threonine phosphatase complex	IBA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0080163	regulation of protein serine/threonine phosphatase activity	IDA	biological process
GO:0032515	negative regulation of phosphoprotein phosphatase activity	IDA	biological process
GO:0019888	protein phosphatase regulator activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001835	blastocyst hatching	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0008287	protein serine/threonine phosphatase complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)