• Gene id: 57691

Gene Summary

• Gene Symbol: KIAA1586   Gene   UCSC   Ensembl
• Gene name: KIAA1586
• Alternate names: E3 SUMO-protein ligase KIAA1586,
• Gene location: 6p12.1 (57046531: 57055738)     Exons: 5     NC_000006.12
• OMIM: 0

Protein Summary

• Protein general information: Q9HCI6  
  • Name: E3 SUMO protein ligase KIAA1586 (EC 2.3.2. ) (E3 SUMO protein transferase KIAA1586)
  • Length: 787  
  • Mass: 89673
• Sequence:

  MGDPGSEIIESVPPAGPEASESTTDENEDDIQFVSEGPSRPVLEYIDLVCGDDENPSAYYSDILFPKMPKRQGDF
  LHFLNVKKVKTDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYK
  WLEIKEGKLGCKDCSAVRHLGSKAEKHVHVSKEWIAYLVTPNGSNKTTRQASLRKKIREHDVSKAHGKIQDLLKE
  STNDSICNLVHKQNNKNIDATVKVFNTVYSLVKHNRPLSDIEGARELQEKNGEVNCLNTRYSATRIAEHIAKEMK
  MKIFKNIIEENAKICIIIDEASTVSKKTTLVIYLQCTIQSAPAPVMLFVALKELVSTIAECIVNTLLTTLNDCGF
  TNEYLKANLIAFCSDGANTILGRKSGVATKLLENFPEIIIWNCLNHRLQLSLDDSISEIKQINHLKIFIDKIYSI
  YHQPNKNQTKLLGTVAKELETEIIKIGRVMGPRWAACSLQAATAVWHAYPILYMHFSHSYSGLAKRLANINFLQD
  LALMIDILEEFSVLSTALQSRSTNIKKAQKLIKRTIRALENLKIGTGKYESQIEDLIKSDKFKDIPFNKNNKFNA
  LPRSILLDNIIQHMNLRLLSDRNHEDIFNYFDLLEPSTWPYEEITSPWIAGEKTLFHLCKILKYEVDLNDFREFV
  NNNIKSNNVSIPTTIYKAKKIVSTIAINSAEAERGFNLMNIICTRVRNSLTIDHVSDLMTINLLGKELADWDATP
  FVKSWSNCNHRLATDTRVRQKSTKVFHENQLAIWNLK

• Structural information:
  • Interpro: IPR012337  
  • STRING: ENSP00000359768
• Other Databases: GeneCards:  KIAA1586  Malacards:  KIAA1586

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0061665	SUMO ligase activity	IDA	molecular function
GO:0016925	protein sumoylation	IDA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0016925	protein sumoylation	IEA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)