• Gene id: 57665

Gene Summary

• Gene Symbol: RDH14   Gene   UCSC   Ensembl
• Aliases: PAN2, SDR7C4
• Gene name: retinol dehydrogenase 14
• Alternate names: retinol dehydrogenase 14, alcohol dehydrogenase PAN2, pancreas protein 2, retinol dehydrogenase 14 (all-trans and 9-cis), retinol dehydrogenase 14 (all-trans/9-cis/11-cis), short chain dehydrogenase/reductase family 7C member 4,
• Gene location: 2p24.2 (18560652: 18554722)     Exons: 2     NC_000002.12
• OMIM: 616796

Protein Summary

• Protein general information: Q9HBH5  
  • Name: Retinol dehydrogenase 14 (EC 1.1.1.300) (Alcohol dehydrogenase PAN2) (Short chain dehydrogenase/reductase family 7C member 4)
  • Length: 336  
  • Mass: 36865
  • Tissue specificity: Widely expressed. {ECO
• Sequence:

  MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARVIMGCR
  DRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPY
  MKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANI
  LFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSG
  RYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK

• Structural information:
  • Interpro: IPR036291  IPR002347  
  • STRING: ENSP00000370648
• Other Databases: GeneCards:  RDH14  Malacards:  RDH14

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016229	steroid dehydrogenase activity	IDA	NOT|molecular function
GO:0052650	NADP-retinol dehydrogenase activity	IDA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0052650	NADP-retinol dehydrogenase activity	IEA	molecular function
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0042572	retinol metabolic process	IEA	biological process
GO:0008106	alcohol dehydrogenase (NADP+) activity	IEA	molecular function
GO:0052650	NADP-retinol dehydrogenase activity	IEA	molecular function
GO:0042572	retinol metabolic process	IEA	biological process
GO:0016020	membrane	HDA	cellular component
GO:0005634	nucleus	HDA	cellular component
GO:0001649	osteoblast differentiation	HDA	biological process
GO:0005765	lysosomal membrane	HDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)