• Gene id: 57633

Gene Summary

• Gene Symbol: LRRN1   Gene   UCSC   Ensembl
• Aliases: FIGLER3, NLRR-1
• Gene name: leucine rich repeat neuronal 1
• Alternate names: leucine-rich repeat neuronal protein 1, fibronectin type III, immunoglobulin and leucine rich repeat domains 3, neuronal leucine-rich repeat protein 1,
• Gene location: 3p26.2 (3799430: 3849833)     Exons: 3     NC_000003.12
• OMIM: 617269

Protein Summary

• Protein general information: Q6UXK5  
  • Name: Leucine rich repeat neuronal protein 1 (Neuronal leucine rich repeat protein 1) (NLRR 1)
  • Length: 716  
  • Mass: 80716
• Sequence:

  MARMSFVIAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQ
  VLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYI
  NHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGM
  YLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGEL
  VSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRC
  DCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAM
  AEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTLLDGTQ
  VLKIYVKQTESHSILVSWKVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSN
  IHQQTQKSCVNVTTKNAAFAVDISDQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKNYHHSLKKYMQKTSSI
  PLNELYPPLINLWEGDSEKDKDGSADTKPTQVDTSRSYYMW

• Structural information:
  • Protein Domains: (26..7-)
    (/note="LRRNT-)
    (371..42-)
    (/note="LRRCT-)
    (424..51-)
    (/note="Ig-like-C2-type)
    (525..61-)
    (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"-)
  • Interpro: IPR000483  IPR003961  IPR036116  IPR007110  IPR036179   IPR013783  IPR013098  IPR003599  IPR003598  IPR001611  IPR003591  IPR032675  
  • Prosite: PS50853 PS50835 PS51450
  • CDD: cd00063
  • STRING: ENSP00000314901
• Other Databases: GeneCards:  LRRN1  Malacards:  LRRN1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0031012	extracellular matrix	IBA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0051965	positive regulation of synapse assembly	IEA	biological process
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray