• Gene id: 57604

Gene Summary

• Gene Symbol: TRMT9B   Gene   UCSC   Ensembl
• Aliases: C8orf79, KIAA1456, TRM9L, hTRM9L
• Gene name: tRNA methyltransferase 9B (putative)
• Alternate names: probable tRNA methyltransferase 9B, probable tRNA methyltransferase 9-like protein,
• Gene location: 8p22 (12945672: 13029776)     Exons: 11     NC_000008.11
• OMIM: 615666

Protein Summary

• Protein general information: Q9P272  
  • Name: Probable tRNA methyltransferase 9B (Probable tRNA methyltransferase 9 like protein) (EC 2.1.1. )
  • Length: 454  
  • Mass: 51299
  • Tissue specificity: Down-regulated in breast, bladder, colorectal, cervix and testicular carcinomas. {ECO
• Sequence:

  MDHEAAQLEKQHVHNVYESTAPYFSDLQSKAWPRVRQFLQEQKPGSLIADIGCGTGKYLKVNSQVHTVGCDYCGP
  LVEIARNRGCEAMVCDNLNLPFRDEGFDAIISIGVIHHFSTKQRRIRAIKEMARVLVPGGQLMIYVWAMEQKNRH
  FEKQDVLVPWNRALCSQLFSESSQSGRKRQCGYPERGHPYHPPCSECSCSVCFKEQCGSKRSHSVGYEPAMARTC
  FANISKEGEEEYGFYSTLGKSFRSWFFSRSLDESTLRKQIERVRPLKNTEVWASSTVTVQPSRHSSLDFDHQEPF
  STKGQSLDEEVFVESSSGKHLEWLRAPGTLKHLNGDHQGEMRRNGGGNFLDSTNTGVNCVDAGNIEDDNPSASKI
  LRRISAVDSTDFNPDDTMSVEDPQTDVLDSTAFMRYYHVFREGELCSLLKENVSELRILSSGNDHGNWCIIAEKK
  RGCD

• Structural information:
  • Interpro: IPR013216  IPR029063  
  • STRING: ENSP00000432695
• Other Databases: GeneCards:  TRMT9B  Malacards:  TRMT9B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016300	tRNA (uracil) methyltransferase activity	IBA	molecular function
GO:0002098	tRNA wobble uridine modification	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0032259	methylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0008175	tRNA methyltransferase activity	EXP	molecular function
GO:0005737	cytoplasm	TAS	cellular component
GO:0006400	tRNA modification	TAS	biological process
GO:0030488	tRNA methylation	IEA	biological process
GO:0030488	tRNA methylation	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq