• Gene id: 57466

Gene Summary

• Gene Symbol: SCAF4   Gene   UCSC   Ensembl
• Aliases: SFRS15, SRA4
• Gene name: SR-related CTD associated factor 4
• Alternate names: SR-related and CTD-associated factor 4, CTD-binding SR-like protein rA4, SR-like CTD-associated factor 4, pre-mRNA splicing SR protein rA4, splicing factor serine alanine 15, splicing factor, arginine/serine-rich 15,
• Gene location: 21q22.11 (31732117: 31668986)     Exons: 3     NC_000021.9
• Gene summary(Entrez): This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA splicing. Alternatively spliced tra
• OMIM: 616023

Protein Summary

• Protein general information: O95104  
  • Name: SR related and CTD associated factor 4 (CTD binding SR like protein RA4) (Splicing factor, arginine/serine rich 15)
  • Length: 1147  
  • Mass: 125869
• Sequence:

  MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKVPGLYVIDSIVRQSRH
  QFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTN
  NEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMA
  QVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTA
  TVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPP
  FPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASRSPKRRRSRS
  GSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVA
  SLLEEFGPIESINMIPPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVT
  YIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPI
  TVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPP
  VSIPPPHTPPISIPNSTIAGINEDTTKDLSIGNPIPTVVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQP
  VSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMP
  PPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPP
  TQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDRHRDLEERN
  RRSSGHRDRERDSRDRESRREKEEARGKEKPEVTDRAGGNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEEL
  PAEATSSVEPEKDSGSAAEAPR

• Structural information:
  • Protein Domains: (1..13-)
    (/note="CID-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00724-)
    (508..58-)
    (/note="RRM-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00176"-)
  • Interpro: IPR006569  IPR008942  IPR012677  IPR035979  IPR006903   IPR000504  IPR034369  
  • Prosite: PS51391 PS50102
  • CDD: cd12461
  • STRING: ENSP00000286835
• Other Databases: GeneCards:  SCAF4  Malacards:  SCAF4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003723	RNA binding	IDA	molecular function
GO:2000805	negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled	IDA	biological process
GO:1990269	RNA polymerase II C-terminal domain phosphoserine binding	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0008022	protein C-terminus binding	IEA	molecular function
GO:0006397	mRNA processing	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)