• Gene id: 57407

Gene Summary

• Gene Symbol: NMRAL1   Gene   UCSC   Ensembl
• Aliases: HSCARG, SDR48A1
• Gene name: NmrA like redox sensor 1
• Alternate names: nmrA-like family domain-containing protein 1, NmrA-like family domain containing 1, epididymis secretory sperm binding protein, short chain dehydrogenase/reductase family 48A, member 1,
• Gene location: 16p13.3 (4476336: 4461679)     Exons: 10     NC_000016.10
• Gene summary(Entrez): This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively re

Protein Summary

• Protein general information: Q9HBL8  
  • Name: NmrA like family domain containing protein 1
  • Length: 299  
  • Mass: 33344
• Sequence:

  MVDKKLVVVFGGTGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYAT
  FIVTNYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSV
  RLPCYFENLLSHFLPQKAPDGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYA
  ALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLANMFRFYALRPDRDIELTLRLNPKALTLDQWLEQHKGDFNLL

• Structural information:
  • Interpro: IPR036291  IPR008030  
  • PDB: 2EXX 2WM3 2WMD 3DXF 3E5M
  • PDBsum: 2EXX 2WM3 2WMD 3DXF 3E5M
  • DIP: 60944
  • STRING: ENSP00000458762
• Other Databases: GeneCards:  NMRAL1  Malacards:  NMRAL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0000050	urea cycle	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

Diseases

Associated diseases	References
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray