• Gene id: 57223

Gene Summary

• Gene Symbol: PPP4R3B   Gene   UCSC   Ensembl
• Aliases: FLFL2, PP4R3B, PSY2, SMEK2, smk1
• Gene name: protein phosphatase 4 regulatory subunit 3B
• Alternate names: serine/threonine-protein phosphatase 4 regulatory subunit 3B, SMEK homolog 2, suppressor of mek1,
• Gene location: 2p16.1 (55618131: 55547291)     Exons: 20     NC_000002.12
• OMIM: 610352

Protein Summary

• Protein general information: Q5MIZ7  
  • Name: Serine/threonine protein phosphatase 4 regulatory subunit 3B (SMEK homolog 2)
  • Length: 849  
  • Mass: 97458
  • Tissue specificity: Moderately expressed in tissues and specific brain regions examined. {ECO
• Sequence:

  MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEA
  ENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVT
  SVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIMDVVGC
  LEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFLSTLTSFIFFNKV
  EIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGMD
  DLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENM
  LATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDFFLKHYRYSWSFICTPSHSHSHSTPSSSISQDNIV
  GSNKNNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFLALCALRFMRRIIGL
  KDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESIEYVQTFKGL
  KTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVVAPVEKPKPEDDFPDNYEKFME
  TKKAKESEDKENLPKRTSPGGFKFTFSHSASAANGTNSKSVVAQIPPATSNGSSSKTTNLPTSVTATKGSLVGLV
  DYPDDEEEDEEEESSPRKRPRLGS

• Structural information:
  • Protein Domains: (1..10-)
    (/note="WH1"-)
  • Interpro: IPR016024  IPR006887  IPR011993  
  • STRING: ENSP00000483228
• Other Databases: GeneCards:  PPP4R3B  Malacards:  PPP4R3B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0006470	protein dephosphorylation	IEA	biological process
GO:0030289	protein phosphatase 4 complex	IEA	cellular component
GO:0045722	positive regulation of gluconeogenesis	IEA	biological process
GO:0019216	regulation of lipid metabolic process	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005815	microtubule organizing center	IEA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0016607	nuclear speck	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04922	Glucagon signaling pathway

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)