• Gene id: 57139

Gene Summary

• Gene Symbol: RGL3   Gene   UCSC   Ensembl
• Gene name: ral guanine nucleotide dissociation stimulator like 3
• Alternate names: ral guanine nucleotide dissociation stimulator-like 3, RalGEF-like protein 3, mouse homolog, ralGDS-like 3,
• Gene location: 19p13.2 (11419313: 11394059)     Exons: 3     NC_000019.10
• OMIM: 616743

Protein Summary

• Protein general information: Q3MIN7  
  • Name: Ral guanine nucleotide dissociation stimulator like 3 (RalGDS like 3)
  • Length: 710  
  • Mass: 78079
• Sequence:

  MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLE
  RLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGVEIKKTAVQDLSFNKNLRAVVSVLGS
  WLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDS
  SEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT
  VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRK
  LSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFE
  KRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRL
  SAKLAREKSSSPSGSPGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLG
  SPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLI
  PDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS

• Structural information:
  • Protein Domains: (65..20-)
    (/note="N-terminal-Ras-GEF)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00135-)
    (247..50-)
    (/note="Ras-GEF-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00168-)
    (613..70-)
    (/note="Ras-associating-)
    (/evidence="ECO:0000255|PROSIT-)
  • Interpro: IPR000159  IPR008937  IPR000651  IPR019804  IPR023578   IPR001895  IPR036964  IPR030750  IPR029071  
  • Prosite: PS50200 PS00720 PS50009 PS50212
  • CDD: cd00155 cd06224
  • STRING: ENSP00000377075
• Other Databases: GeneCards:  RGL3  Malacards:  RGL3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007165	signal transduction	IEA	biological process
GO:0008321	Ral guanyl-nucleotide exchange factor activity	IEA	molecular function
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	molecular function
GO:0007264	small GTPase mediated signal transduction	IEA	biological process
GO:0043547	positive regulation of GTPase activity	IEA	biological process
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0008321	Ral guanyl-nucleotide exchange factor activity	IEA	molecular function
GO:0017016	Ras GTPase binding	IEA	molecular function
GO:0031267	small GTPase binding	IEA	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq