• Gene id: 56936

Gene Summary

• Gene Symbol: CCDC177   Gene   UCSC   Ensembl
• Aliases: C14orf162, PLPL
• Gene name: coiled-coil domain containing 177
• Alternate names: coiled-coil domain-containing protein 177, myelin proteolipid protein-like protein,
• Gene location: 14q24.1 (69574870: 69569798)     Exons: 6     NC_000014.9

Protein Summary

• Protein general information: Q9NQR7  
  • Name: Coiled coil domain containing protein 177 (Myelin proteolipid protein like protein)
  • Length: 707  
  • Mass: 79739
• Sequence:

  MVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLD
  LFNFDCPEAEGSRYVLTSPRSLEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRA
  ERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGSR
  TGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTLVPITG
  RSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ
  RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAARED
  RLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ
  EREGLRSSLEASLGRAQENYEHLVEQRTRELRERARREELQGRRAKEAAERKEREHQAHLEALARAGERRLQHAT
  QVAEEAVQQKARRVGQSRLEKERAQRANKEKVERDEDCRRRELLQAIGRKLERSEQLTRERRSALESARSTARAS
  FHVREKVREETNTRSFDRMVREAQLHASLDRK

• Structural information:
  • Interpro: IPR029090  
  • STRING: ENSP00000469474
• Other Databases: GeneCards:  CCDC177  Malacards:  CCDC177

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray