• Gene id: 56931

Gene Summary

• Gene Symbol: DUS3L   Gene   UCSC   Ensembl
• Aliases: DUS3
• Gene name: dihydrouridine synthase 3 like
• Alternate names: tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like,
• Gene location: 19p13.3 (5791209: 5785135)     Exons: 13     NC_000019.10
• OMIM: 616347

Protein Summary

• Protein general information: Q96G46  
  • Name: tRNA dihydrouridine(47) synthase [NAD(P)(+)] like (EC 1.3.1. ) (tRNA dihydrouridine synthase 3 like)
  • Length: 650  
  • Mass: 72594
• Sequence:

  MAEGTAEAPLENGGGGDSGAGALERGVAPIKRQYLTTKEQFHQFLEAKGQEKTCRETEVGDPAGNELAEPEAKRI
  RLEDGQTADGQTEEAAEPGEQLQTQKRARGQNKGRPHVKPTNYDKNRLCPSLIQESAAKCFFGDRCRFLHDVGRY
  LETKPADLGPRCVLFETFGRCPYGVTCRFAGAHLRPEGQNLVQEELAARGTQPPSIRNGLDKALQQQLRKREVRF
  ERAEQALRRFSQGPTPAAAVPEGTAAEGAPRQENCGAQQVPAGPGTSTPPSSPVRTCGPLTDEDVVRLRPCEKKR
  LDIRGKLYLAPLTTCGNLPFRRICKRFGADVTCGEMAVCTNLLQGQMSEWALLKRHQCEDIFGVQLEGAFPDTMT
  KCAELLSRTVEVDFVDINVGCPIDLVYKKGGGCALMNRSTKFQQIVRGMNQVLDVPLTVKIRTGVQERVNLAHRL
  LPELRDWGVALVTLHGRSREQRYTKLADWQYIEECVQAASPMPLFGNGDILSFEDANRAMQTGVTGIMIARGALL
  KPWLFTEIKEQRHWDISSSERLDILRDFTNYGLEHWGSDTQGVEKTRRFLLEWLSFLCRYVPVGLLERLPQRINE
  RPPYYLGRDYLETLMASQKAADWIRISEMLLGPVPPSFAFLPKHKANAYK

• Structural information:
  • Interpro: IPR013785  IPR035587  IPR001269  IPR018517  IPR041367   IPR000571  
  • Prosite: PS01136 PS50103
  • CDD: cd02801
  • STRING: ENSP00000311977
• Other Databases: GeneCards:  DUS3L  Malacards:  DUS3L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0017150	tRNA dihydrouridine synthase activity	IBA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0017150	tRNA dihydrouridine synthase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0050660	flavin adenine dinucleotide binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0002943	tRNA dihydrouridine synthesis	IEA	biological process
GO:0002943	tRNA dihydrouridine synthesis	IEA	biological process
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq