• Gene id: 56911

Gene Summary

• Gene Symbol: MAP3K7CL   Gene   UCSC   Ensembl
• Aliases: C21orf7, HC21ORF7, TAK1L, TAKL, TAKL-1, TAKL-2, TAKL-4
• Gene name: MAP3K7 C-terminal like
• Alternate names: MAP3K7 C-terminal-like protein, TAK1-like protein 1, TAK1-like protein 2, TAK1-like protein 4, TGF-beta activated kinase,
• Gene location: 21q21.3 (29077113: 29175888)     Exons: 18     NC_000021.9
• OMIM: 603320

Protein Summary

• Protein general information: P57077  
  • Name: MAP3K7 C terminal like protein (TAK1 like protein)
  • Length: 242  
  • Mass: 27248
  • Tissue specificity: Detected in lung and peripheral blood leukocytes. Expressed predominantly in peripheral blood leukocytes and ubiquitously in adult and fetal tissues. Also expressed strongly in breast carcinoma GI-101, colon adenocarcinoma GI-112, and
• Sequence:

  MVQLIAPLEVMWNEAADLKPLALSRRLECSGGIMAHYSPDLLGPEMESRYFAQVGLEHLASSSPPAFGFLKCLDY
  SISVLCSATSLAMLEDNPKVSKLATGDWMLTLKPKSITVPVEIPSSPLDDTPPEDSIPLVFPELDQQLQPLPPCH
  DSEESMEVFKQHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRLAQSQCV
  EQLEKLRIQYQKRQGSS

• Structural information:
  • Interpro: IPR042800  
  • STRING: ENSP00000382828
• Other Databases: GeneCards:  MAP3K7CL  Malacards:  MAP3K7CL

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0005829	cytosol	HDA	cellular component
GO:0005634	nucleus	HDA	cellular component

Diseases

Associated diseases	References
Hypospermatogenesis	MIK: 28361989

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray