• Gene id: 56675

Gene Summary

• Gene Symbol: NRIP3   Gene   UCSC   Ensembl
• Aliases: C11orf14, NY-SAR-105
• Gene name: nuclear receptor interacting protein 3
• Alternate names: nuclear receptor-interacting protein 3, sarcoma antigen NY-SAR-105,
• Gene location: 11p15.4 (104164146: 103907188)     Exons: 7     NC_000011.10
• OMIM: 613125

Protein Summary

• Protein general information: Q9NQ35  
  • Name: Nuclear receptor interacting protein 3 (Sarcoma antigen NY SAR 105)
  • Length: 241  
  • Mass: 26975
• Sequence:

  MFYSGLLTEGGRKETDMREAASLRQQRRMKQAVQFIHKDSADLLPLDGLKKLGSSKDMQPHNILQRRLMETNLSK
  LRSGPRVPWASKTNKLNQAKSEGLKKSEEDDMILVSCQCAGKDVKALVDTGCLYNLISLACVDRLGLKEHVKSHK
  HEGEKLSLPRHLKVVGQIEHLVITLGSLRLDCPAAVVDDNEKNLSLGLQTLRSLKCIINLDKHRLIMGKTDKEEI
  PFVETVSLNEDNTSEA

• Structural information:
  • Interpro: IPR033821  IPR019103  IPR021109  
  • CDD: cd05480
  • STRING: ENSP00000310205
• Other Databases: GeneCards:  NRIP3  Malacards:  NRIP3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004190	aspartic-type endopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Globozoospermia	MIK: 31985809
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
31985809	Globozoospermia	p.(Ile132Asn)		16 infertile patients	Male infertility	NGS