• Gene id: 56165

Gene Summary

• Gene Symbol: TDRD1   Gene   UCSC   Ensembl
• Aliases: CT41.1
• Gene name: tudor domain containing 1
• Alternate names: tudor domain-containing protein 1, cancer/testis antigen 41.1, testicular tissue protein Li 193,
• Gene location: 10q25.3 (114174441: 114232668)     Exons: 30     NC_000010.11
• Gene summary(Entrez): This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and sil
• OMIM: 605796

Protein Summary

• Protein general information: Q9BXT4  
  • Name: Tudor domain containing protein 1 (Cancer/testis antigen 41.1) (CT41.1)
  • Length: 1180  
  • Mass: 132024
  • Tissue specificity: Testis and ovary specific. Also expressed in several cancers. {ECO
• Sequence:

  MSVKSPFNVMSRNNLEAPPCKMTEPFNFEKNENKLPPHESLRSPGTLPNHPNFRLKSSENGNKKNNFLLCEQTKQ
  YLASQEDNSVSSNPNGINGEVVGSKGDRKKLPAGNSVSPPSAESNSPPKEVNIKPGNNVRPAKSKKLNKLVENSL
  SISNPGLFTSLGPPLRSTTCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSAHSIVCRPVQPNFHKLENKSSIETK
  DVEVNNKSDCPLGVTKEIAIWAERIMFSDLRSLQLKKTMEIKGTVTEFKHPGDFYVQLYSSEVLEYMNQLSASLK
  ETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPC
  AIKCFVANVIPAEGNWSSDCIKATKPLLMEQYCSIKIVDILEEEVVTFAVEVELPNSGKLLDHVLIEMGYGLKPS
  GQDSKKENADQSDPEDVGKMTTENNIVVDKSDLIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGRKLAELQA
  SLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLEL
  PMQAIKCVLAGVKPSLGIWTPEAICLMKKLVQNKIITVKVVDKLENSSLVELIDKSETPHVSVSKVLLDAGFAVG
  EQSMVTDKPSDVKETSVPLGVEGKVNPLEWTWVELGVDQTVDVVVCVIYSPGEFYCHVLKEDALKKLNDLNKSLA
  EHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQG
  IRCQLADIQSRNKHWSEEAITRFQMCVAGIKLQARVVEVTENGIGVELTDLSTCYPRIISDVLIDEHLVLKSASP
  HKDLPNDRLVNKHELQVHVQGLQATSSAEQWKTIELPVDKTIQANVLEIISPNLFYALPKGMPENQEKLCMLTAE
  LLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPF
  QIIRCSLEGLMELNGSSSQLIIMLLKNFMLNQNVMLSVKGITKNVHTVSVEKCSENGTVDVADKLVTFGLAKNIT
  PQRQSALNTEKMYRMNCCCTELQKQVEKHEHILLFLLNNSTNQNKFIEMKKLLKS

• Structural information:
  • Protein Domains: (312..37-)
    (/note="Tudor-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00211-)
    (541..60-)
    (/note="Tudor-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00211-)
    (762..82-)
    (/note="Tudor-3)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00211-)
  • Interpro: IPR035437  IPR002999  IPR002893  
  • Prosite: PS50304 PS01360 PS50865
  • PDB: 5M9N
  • PDBsum: 5M9N
  • STRING: ENSP00000251864
• Other Databases: GeneCards:  TDRD1  Malacards:  TDRD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0071546	pi-body	ISS	cellular component
GO:0043186	P granule	ISS	cellular component
GO:0043046	DNA methylation involved in gamete generation	ISS	biological process
GO:0007283	spermatogenesis	ISS	biological process
GO:0034587	piRNA metabolic process	ISS	biological process
GO:0031047	gene silencing by RNA	ISS	biological process
GO:0007281	germ cell development	ISS	biological process
GO:0005737	cytoplasm	ISS	cellular component
GO:0007283	spermatogenesis	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0051321	meiotic cell cycle	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0007275	multicellular organism development	IEA	biological process
GO:0031047	gene silencing by RNA	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0043046	DNA methylation involved in gamete generation	IEA	biological process
GO:0043186	P granule	IEA	cellular component
GO:0071546	pi-body	IEA	cellular component
GO:1990904	ribonucleoprotein complex	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0007281	germ cell development	IEA	biological process
GO:0031047	gene silencing by RNA	IEA	biological process
GO:0033391	chromatoid body	IEA	cellular component
GO:0034587	piRNA metabolic process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Alzheimer's disease	GAD: 16385451
Spermatogenesis defects	MIK: 19345100
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881