• Gene id: 55844

Gene Summary

• Gene Symbol: PPP2R2D   Gene   UCSC   Ensembl
• Aliases: B55D, B55delta, MDS026
• Gene name: protein phosphatase 2 regulatory subunit Bdelta
• Alternate names: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform, PP2A subunit B isoform B55-delta, PP2A subunit B isoform PR55-delta, PP2A subunit B isoform R2-delta, PP2A subunit B isoform delta, protein phosphatase 2 regulatory subunit B, d,
• Gene location: 10q26.3 (131900933: 131971534)     Exons: 12     NC_000010.11
• OMIM: 611344

Protein Summary

• Protein general information: Q66LE6  
  • Name: Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55 delta) (PP2A subunit B isoform PR55 delta) (PP2A subunit B isoform R2 delta) (PP2A subunit B isoform delta)
  • Length: 453  
  • Mass: 52042
• Sequence:

  MAGAGGGGCPAGGNDFQWCFSQVKGAIDEDVAEADIISTVEFNYSGDLLATGDKGGRVVIFQREQENKSRPHSRG
  EYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAHFLLSTNDKTIKLWKISERDKRAEGYNLKDEDGRLR
  DPFRITALRVPILKPMDLMVEASPRRIFANAHTYHINSISVNSDHETYLSADDLRINLWHLEITDRSFNIVDIKP
  ANMEELTEVITAAEFHPHQCNVFVYSSSKGTIRLCDMRSSALCDRHSKFFEEPEDPSSRSFFSEIISSISDVKFS
  HSGRYMMTRDYLSVKVWDLNMESRPVETHQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSAIMTGSYNNFFRMF
  DRDTRRDVTLEASRESSKPRASLKPRKVCTGGKRRKDEISVDSLDFNKKILHTAWHPVDNVIAVAATNNLYIFQD
  KIN

• Structural information:
  • Interpro: IPR000009  IPR018067  IPR015943  IPR001680  IPR036322  
  • Prosite: PS01024 PS01025
  • STRING: ENSP00000399970
• Other Databases: GeneCards:  PPP2R2D  Malacards:  PPP2R2D

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0070262	peptidyl-serine dephosphorylation	IBA	biological process
GO:0005829	cytosol	IBA	cellular component
GO:0019888	protein phosphatase regulator activity	IBA	molecular function
GO:0000159	protein phosphatase type 2A complex	IBA	cellular component
GO:0000278	mitotic cell cycle	ISS	biological process
GO:0010458	exit from mitosis	ISS	biological process
GO:0019888	protein phosphatase regulator activity	ISS	molecular function
GO:0000159	protein phosphatase type 2A complex	ISS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0000159	protein phosphatase type 2A complex	IEA	cellular component
GO:0019888	protein phosphatase regulator activity	IEA	molecular function
GO:0051301	cell division	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0007049	cell cycle	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0043666	regulation of phosphoprotein phosphatase activity	IEA	biological process
GO:0043666	regulation of phosphoprotein phosphatase activity	IEA	biological process
GO:0043666	regulation of phosphoprotein phosphatase activity	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa05165	Human papillomavirus infection
hsa04530	Tight junction
hsa04390	Hippo signaling pathway
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04728	Dopaminergic synapse
hsa05160	Hepatitis C
hsa04071	Sphingolipid signaling pathway
hsa04152	AMPK signaling pathway
hsa03015	mRNA surveillance pathway
hsa05142	Chagas disease

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq