• Gene id: 55816

Gene Summary

• Gene Symbol: DOK5   Gene   UCSC   Ensembl
• Aliases: C20orf180, IRS-6, IRS6
• Gene name: docking protein 5
• Alternate names: docking protein 5, downstream of tyrosine kinase 5, insulin receptor substrate 6,
• Gene location: 20q13.2 (54475592: 54651170)     Exons: 11     NC_000020.11
• Gene summary(Entrez): The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and a
• OMIM: 176980

Protein Summary

• Protein general information: Q9P104  
  • Name: Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS 6) (IRS6)
  • Length: 306  
  • Mass: 35464
  • Tissue specificity: Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. {ECO
• Sequence:

  MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKST
  KKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLD
  VHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHS
  AALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFP
  AYRSEH

• Structural information:
  • Protein Domains: (8..11-)
    (/note="PH-)
    (132..23-)
    (/note="IRS-type-PTB)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00389"-)
  • Interpro: IPR037816  IPR002404  IPR011993  IPR001849  
  • Prosite: PS51064
  • CDD: cd14678
  • PDB: 1J0W
  • PDBsum: 1J0W
  • STRING: ENSP00000262593
• Other Databases: GeneCards:  DOK5  Malacards:  DOK5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051386	regulation of neurotrophin TRK receptor signaling pathway	IMP	biological process
GO:0007411	axon guidance	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0043410	positive regulation of MAPK cascade	IEA	biological process
GO:0030182	neuron differentiation	IEA	biological process
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq