• Gene id: 55798

Gene Summary

• Gene Symbol: METTL2B   Gene   UCSC   Ensembl
• Aliases: METL, METTL2, METTL2A, PSENIP1
• Gene name: methyltransferase like 2B
• Alternate names: tRNA N(3)-methylcytidine methyltransferase METTL2B, methyltransferase-like protein 2B,
• Gene location: 7q32.1 (128476747: 128506601)     Exons: 9     NC_000007.14
• Gene summary(Entrez): This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all va
• OMIM: 607846

Protein Summary

• Protein general information: Q6P1Q9  
  • Name: tRNA N(3) methylcytidine methyltransferase METTL2B (EC 2.1.1. ) (Methyltransferase like protein 2B)
  • Length: 378  
  • Mass: 43426
• Sequence:

  MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAH
  KYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVCECRNNEDGPGLIMEEQHKCSSKSLEH
  KTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTN
  SEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ
  LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLS
  STS

• Structural information:
  • Interpro: IPR026113  IPR029063  
  • STRING: ENSP00000262432
• Other Databases: GeneCards:  METTL2B  Malacards:  METTL2B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0052735	tRNA (cytosine-3-)-methyltransferase activity	IBA	molecular function
GO:0030488	tRNA methylation	IMP	biological process
GO:0016427	tRNA (cytosine) methyltransferase activity	IMP	molecular function
GO:0032259	methylation	IEA	biological process
GO:0008033	tRNA processing	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0008168	methyltransferase activity	IEA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881