• Gene id: 5573

Gene Summary

• Gene Symbol: PRKAR1A   Gene   UCSC   Ensembl
• Aliases: ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1
• Gene name: protein kinase cAMP-dependent type I regulatory subunit alpha
• Alternate names: cAMP-dependent protein kinase type I-alpha regulatory subunit, Carney complex type 1, cAMP-dependent protein kinase regulatory subunit RIalpha, cAMP-dependent protein kinase type I-alpha regulatory chain, epididymis secretory sperm binding protein, protein kin,
• Gene location: 17q24.2 (68413622: 68551315)     Exons: 16     NC_000012.12
• Gene summary(Entrez): cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holo
• OMIM: 188830

Protein Summary

Gene ontology

GO accession	Term name	Evidence code	Go category

KEGG pathways

Pathway id	Pathway name
hsa04910	Insulin signaling pathway
hsa04910	Insulin signaling pathway

Diseases

Associated diseases	References
Adenoma	GAD: 19429701
Cancer (thyroid)	GAD: 19730683
Pituitary adenomas	KEGG: H01102
Carney complex	KEGG: H01820
Multiple endocrine neoplasia	GAD: 20507346
Cushing's syndrome	KEGG: H01431
Adrenal cortex diseases	GAD: 19293268
Fertilizing defects	MIK: 16728532
Acrodysostosis	KEGG: H02211
Pigmented micronodular adrenocortical disease	KEGG: H00260
Fertility defects	MIK: 16728532
Hypospermatogenesis	MIK: 28361989
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
16728532	Fertility defects				Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray