• Gene id: 55683

Gene Summary

• Gene Symbol: KANSL3   Gene   UCSC   Ensembl
• Aliases: KIAA1310, NSL3, Rcd1
• Gene name: KAT8 regulatory NSL complex subunit 3
• Alternate names: KAT8 regulatory NSL complex subunit 3, NSL complex protein NSL3, non-specific lethal 3 homolog, serum inhibited-related protein, testis development protein PRTD,
• Gene location: 2q11.2 (96638377: 96593169)     Exons: 28     NC_000002.12
• OMIM: 617742

Protein Summary

• Protein general information: Q9P2N6  
  • Name: KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non specific lethal 3 homolog) (Serum inhibited related protein) (Testis development protein PRTD)
  • Length: 904  
  • Mass: 95992
• Sequence:

  MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQHESTIESD
  VPIDVETVTSTPMPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTMAQNKLFNKILKALQSD
  RLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLIQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTL
  IDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIASSGPSSSVFPTSRRHRFWQSQLS
  CLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCL
  GFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEG
  LTQSMVDRCIQDEIVDFLTGVLTRAEGHMGSEPRDQDAEKKKKPRDVARRDLAFEVPERGSRPASPAAKLPASPS
  GSEDLSSVSSSPTSSPKTKVTTVTSAQKSSQIGSSQLLKRHVQRTEAVLTHKQAQAQFAAFLKQNMLVRKALPPG
  TSSCLFVPISSEPPEEGEKEDLRVQLKRHHPSSPLPGSKTSKRPKIKVSLISQGDTAGGPCAPSQGSAPEAAGGK
  PITMTLGQASAGAKELTGLLTTAKSSSSEGGVSASPVPSVVSSSTAPSALHTLQSRLVATSPGSSLPGATSASSL
  LQGLSFSLQDISSKTSGLPANPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTA
  IHQLLTNGGLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAPSEESSSQVLPSSSQRL
  PPAP

• Structural information:
  • Interpro: IPR029058  IPR026555  
  • STRING: ENSP00000396749
• Other Databases: GeneCards:  KANSL3  Malacards:  KANSL3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0043981	histone H4-K5 acetylation	IBA	biological process
GO:0043982	histone H4-K8 acetylation	IBA	biological process
GO:0043984	histone H4-K16 acetylation	IBA	biological process
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	IBA	contributes to
GO:0044545	NSL complex	IBA	cellular component
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	IBA	contributes to
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	IBA	contributes to
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	IDA	contributes to
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	IDA	contributes to
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	IDA	contributes to
GO:0043984	histone H4-K16 acetylation	IDA	biological process
GO:0043982	histone H4-K8 acetylation	IDA	biological process
GO:0043981	histone H4-K5 acetylation	IDA	biological process
GO:0000123	histone acetyltransferase complex	IDA	cellular component
GO:0006325	chromatin organization	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)