• Gene id: 55664

Gene Summary

• Gene Symbol: CDC37L1   Gene   UCSC   Ensembl
• Aliases: CDC37B, HARC
• Gene name: cell division cycle 37 like 1
• Alternate names: hsp90 co-chaperone Cdc37-like 1, CDC37 cell division cycle 37 homolog-like 1, Hsp90-associating relative of Cdc37, cell division cycle 37 homolog-like 1,
• Gene location: 9p24.1 (4679568: 4708398)     Exons: 18     NC_000009.12
• Gene summary(Entrez): CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]
• OMIM: 610346

Protein Summary

• Protein general information: Q7L3B6  
  • Name: Hsp90 co chaperone Cdc37 like 1 (Hsp90 associating relative of Cdc37)
  • Length: 337  
  • Mass: 38835
  • Tissue specificity: Expressed in brain, heart, kidney, liver, placenta and skeletal muscle. {ECO
• Sequence:

  MEQPWPPPGPWSLPRAEGEAEEESDFDVFPSSPRCPQLPGGGAQMYSHGIELACQKQKEFVKSSVACKWNLAEAQ
  QKLGSLALHNSESLDQEHAKAQTAVSELRQREEEWRQKEEALVQREKMCLWSTDAISKDVFNKSFINQDKRKDTE
  DEDKSESFMQKYEQKIRHFGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQF
  IMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLE
  SLPQNPDYLQYSISTALCSLNSVVHKEDDEPKMMDTV

• Structural information:
  • Interpro: IPR004918  IPR013874  IPR038189  
  • STRING: ENSP00000371278
• Other Databases: GeneCards:  CDC37L1  Malacards:  CDC37L1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006457	protein folding	IBA	biological process
GO:0050821	protein stabilization	IBA	biological process
GO:0051082	unfolded protein binding	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0031072	heat shock protein binding	IBA	molecular function
GO:0051087	chaperone binding	IBA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0002576	platelet degranulation	TAS	biological process
GO:0031089	platelet dense granule lumen	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)