• Gene id: 55635

Gene Summary

• Gene Symbol: DEPDC1   Gene   UCSC   Ensembl
• Aliases: DEP.8, DEPDC1-V2, DEPDC1A, SDP35
• Gene name: DEP domain containing 1
• Alternate names: DEP domain-containing protein 1A, cell cycle control protein SDP35,
• Gene location: 1p31.3 (68497081: 68474151)     Exons: 12     NC_000001.11
• OMIM: 612002

Protein Summary

• Protein general information: Q5TB30  
  • Name: DEP domain containing protein 1A
  • Length: 811  
  • Mass: 92960
  • Tissue specificity: Expressed in testis. Up-regulated in bladder cancer cells (at protein level). {ECO
• Sequence:

  MESQGVPPGPYRATKLWNEVTTSFRAGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLRNNSNFGPEVTRQQTIQL
  LRKFLKNHVIEDIKGRWGSENVDDNNQLFRFPATSPLKTLPRRYPELRKNNIENFSKDKDSIFKLRNLSRRTPKR
  HGLHLSQENGEKIKHEIINEDQENAIDNRELSQEDVEEVWRYVILIYLQTILGVPSLEEVINPKQVIPQYIMYNM
  ANTSKRGVVILQNKSDDLPHWVLSAMKCLANWPRSNDMNNPTYVGFERDVFRTIADYFLDLPEPLLTFEYYELFV
  NILVVCGYITVSDRSSGIHKIQDDPQSSKFLHLNNLNSFKSTECLLLSLLHREKNKEESDSTERLQISNPGFQER
  CAKKMQLVNLRNRRVSANDIMGGSCHNLIGLSNMHDLSSNSKPRCCSLEGIVDVPGNSSKEASSVFHQSFPNIEG
  QNNKLFLESKPKQEFLLNLHSEENIQKPFSAGFKRTSTLTVQDQEELCNGKCKSKQLCRSQSLLLRSSTRRNSYI
  NTPVAEIIMKPNVGQGSTSVQTAMESELGESSATINKRLCKSTIELSENSLLPASSMLTGTQSLLQPHLERVAID
  ALQLCCLLLPPPNRRKLQLLMRMISRMSQNVDMPKLHDAMGTRSLMIHTFSRCVLCCAEEVDLDELLAGRLVSFL
  MDHHQEILQVPSYLQTAVEKHLDYLKKGHIENPGDGLFAPLPTYSYCKQISAQEFDEQKVSTSQAAIAELLENII
  KNRSLPLKEKRKKLKQFQKEYPLIYQKRFPTTESEAALFGDKPTIKQPMLILRKPKFRSLR

• Structural information:
  • Protein Domains: (24..10-)
    (/note="DEP-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00066-)
    (281..32-)
    (/note="Rho-GAP"-)
  • Interpro: IPR000591  IPR008936  IPR036388  IPR036390  
  • Prosite: PS50186
  • PDB: 2YSR
  • PDBsum: 2YSR
  • STRING: ENSP00000412292
• Other Databases: GeneCards:  DEPDC1  Malacards:  DEPDC1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0017053	transcription repressor complex	IBA	cellular component
GO:0017053	transcription repressor complex	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0007165	signal transduction	IEA	biological process
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0005096	GTPase activator activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0043547	positive regulation of GTPase activity	IEA	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IDA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)