• Gene id: 55316

Gene Summary

• Gene Symbol: RSAD1   Gene   UCSC   Ensembl
• Aliases: HemW
• Gene name: radical S-adenosyl methionine domain containing 1
• Alternate names: radical S-adenosyl methionine domain-containing protein 1, mitochondrial, oxygen-independent coproporphyrinogen-III oxidase-like protein RSAD1, putative heme chaperone,
• Gene location: 17q21.33 (50478799: 50485979)     Exons: 9     NC_000017.11
• OMIM: 609789

Protein Summary

• Protein general information: Q9HA92  
  • Name: Radical S adenosyl methionine domain containing protein 1, mitochondrial (Putative heme chaperone)
  • Length: 442  
  • Mass: 48714
• Sequence:

  MALPGARARGWAAAARAAQRRRRVENAGGSPSPEPAGRRAALYVHWPYCEKRCSYCNFNKYIPRRLEEAAMQKCL
  VTEAQTLLRLSGVQRVESVFFGGGTPSLASPHTVAAVLEAVAQAAHLPADLEVTLEANPTSAPGSRLAEFGAAGV
  NRLSIGLQSLDDTELRLLGRTHSACDALRTLAEARRLFPGRVSVDLMLGLPAQQVGPWLGQLQELLHHCDDHLSL
  YQLSLERGTALFAQVQRGALPAPDPELAAEMYQRGRAVLREAGFHQYEVSNFARNGALSTHNWTYWQCGQYLGVG
  PGAHGRFMPQGAGGHTREARIQTLEPDNWMKEVMLFGHGTRKRVPLGRLELLEEVLALGLRTDVGITHQHWQQFE
  PQLTLWDVFGANKEVQELLERGLLQLDHRGLRCSWEGLAVLDSLLLTLLPQLQEAWQQRTPSPVPGG

• Structural information:
  • Interpro: IPR034505  IPR006638  IPR010723  IPR004559  IPR007197   IPR023404  
  • STRING: ENSP00000258955
• Other Databases: GeneCards:  RSAD1  Malacards:  RSAD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0006779	porphyrin-containing compound biosynthetic process	IBA	biological process
GO:0051539	4 iron, 4 sulfur cluster binding	IBA	molecular function
GO:0004109	coproporphyrinogen oxidase activity	IEA	molecular function
GO:0006779	porphyrin-containing compound biosynthetic process	IEA	biological process
GO:0051539	4 iron, 4 sulfur cluster binding	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0051536	iron-sulfur cluster binding	IEA	molecular function
GO:0051539	4 iron, 4 sulfur cluster binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0051536	iron-sulfur cluster binding	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0006779	porphyrin-containing compound biosynthetic process	IBA	biological process
GO:0051539	4 iron, 4 sulfur cluster binding	IBA	molecular function
GO:0004109	coproporphyrinogen oxidase activity	IEA	molecular function
GO:0006779	porphyrin-containing compound biosynthetic process	IEA	biological process
GO:0051539	4 iron, 4 sulfur cluster binding	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0051536	iron-sulfur cluster binding	IEA	molecular function
GO:0051539	4 iron, 4 sulfur cluster binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0051536	iron-sulfur cluster binding	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0055114	oxidation-reduction process	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881