• Gene id: 55276

Gene Summary

• Gene Symbol: PGM2   Gene   UCSC   Ensembl
• Aliases: MSTP006
• Gene name: phosphoglucomutase 2
• Alternate names: phosphoglucomutase-2, PGM 2, glucose phosphomutase 2, phosphodeoxyribomutase,
• Gene location: 4p14 (37826685: 37862936)     Exons: 15     NC_000004.12
• OMIM: 172000

Protein Summary

• Protein general information: Q96G03  
  • Name: Phosphoglucomutase 2 (PGM 2) (EC 5.4.2.2) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphopentomutase) (EC 5.4.2.7)
  • Length: 612  
  • Mass: 68283
• Sequence:

  MAAPEGSGLGEDARLDQETAQWLRWDKNSLTLEAVKRLIAEGNKEELRKCFGARMEFGTAGLRAAMGPGISRMND
  LTIIQTTQGFCRYLEKQFSDLKQKGIVISFDARAHPSSGGSSRRFARLAATTFISQGIPVYLFSDITPTPFVPFT
  VSHLKLCAGIMITASHNPKQDNGYKVYWDNGAQIISPHDKGISQAIEENLEPWPQAWDDSLIDSSPLLHNPSASI
  NNDYFEDLKKYCFHRSVNRETKVKFVHTSVHGVGHSFVQSAFKAFDLVPPEAVPEQKDPDPEFPTVKYPNPEEGK
  GVLTLSFALADKTKARIVLANDPDADRLAVAEKQDSGEWRVFSGNELGALLGWWLFTSWKEKNQDRSALKDTYML
  SSTVSSKILRAIALKEGFHFEETLTGFKWMGNRAKQLIDQGKTVLFAFEEAIGYMCCPFVLDKDGVSAAVISAEL
  ASFLATKNLSLSQQLKAIYVEYGYHITKASYFICHDQETIKKLFENLRNYDGKNNYPKACGKFEISAIRDLTTGY
  DDSQPDKKAVLPTSKSSQMITFTFANGGVATMRTSGTEPKIKYYAELCAPPGNSDPEQLKKELNELVSAIEEHFF
  QPQKYNLQPKAD

• Structural information:
  • Interpro: IPR005844  IPR016055  IPR005845  IPR005846  IPR005843   IPR036900  IPR016066  IPR005841  
  • Prosite: PS00710
  • STRING: ENSP00000371393
• Other Databases: GeneCards:  PGM2  Malacards:  PGM2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000287	magnesium ion binding	IEA	molecular function
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0016868	intramolecular transferase activity, phosphotransferases	IEA	molecular function
GO:0071704	organic substance metabolic process	IEA	biological process
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0006006	glucose metabolic process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016853	isomerase activity	IEA	molecular function
GO:0004614	phosphoglucomutase activity	IEA	molecular function
GO:0008973	phosphopentomutase activity	IEA	molecular function
GO:0005980	glycogen catabolic process	TAS	biological process
GO:0019388	galactose catabolic process	TAS	biological process
GO:0043312	neutrophil degranulation	TAS	biological process
GO:1904813	ficolin-1-rich granule lumen	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005978	glycogen biosynthetic process	TAS	biological process
GO:0006098	pentose-phosphate shunt	TAS	biological process
GO:0034774	secretory granule lumen	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0004614	phosphoglucomutase activity	IEA	molecular function
GO:0006006	glucose metabolic process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0046386	deoxyribose phosphate catabolic process	IEA	biological process
GO:0008973	phosphopentomutase activity	IDA	molecular function
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00230	Purine metabolism
hsa00010	Glycolysis / Gluconeogenesis
hsa00520	Amino sugar and nucleotide sugar metabolism
hsa00030	Pentose phosphate pathway
hsa00500	Starch and sucrose metabolism
hsa00052	Galactose metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881