• Gene id: 5523

Gene Summary

• Gene Symbol: PPP2R3A   Gene   UCSC   Ensembl
• Aliases: PPP2R3, PR130, PR72
• Gene name: protein phosphatase 2 regulatory subunit B''alpha
• Alternate names: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha, PP2A subunit B isoforms B72/B130, PP2A, subunit B, R3 isoform, PR130/B''alpha1 subunit, PR72/B''alpha2 subuit, protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), al,
• Gene location: 3q22.2-q22.3 (114821779: 114899831)     Exons: 18     NC_000010.11
• Gene summary(Entrez): This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phos
• OMIM: 604944

Protein Summary

• Protein general information: Q06190  
  • Name: Serine/threonine protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B'' PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine protein phos
  • Length: 1150  
  • Mass: 130278
  • Tissue specificity: Expressed in heart, brain, placenta, lung, muscle and kidney.
• Sequence:

  MAATYRLVVSTVNHYSSVVIDRRFEQAIHYCTGTCHTFTHGIDCIVVHHSVCADLLHIPVSQFKDADLNSMFLPH
  ENGLSSAEGDYPQQAFTGIPRVKRGSTFQNTYNLKDIAGEAISFASGKIKEFSFEKLKNSNHAAYRKGRKVKSDS
  FNRRSVDLDLLCGHYNNDGNAPSFGLLRSSSVEEKPLSHRNSLDTNLTSMFLQNFSEEDLVTQILEKHKIDNFSS
  GTDIKMCLDILLKCSEDLKKCTDIIKQCIKKKSGSSISEGSGNDTISSSETVYMNVMTRLASYLKKLPFEFMQSG
  NNEALDLTELISNMPSLQLTPFSPVFGTEQPPKYEDVVQLSASDSGRFQTIELQNDKPNSRKMDTVQSIPNNSTN
  SLYNLEVNDPRTLKAVQVQSQSLTMNPLENVSSDDLMETLYIEEESDGKKALDKGQKTENGPSHELLKVNEHRAE
  FPEHATHLKKCPTPMQNEIGKIFEKSFVNLPKEDCKSKVSKFEEGDQRDFTNSSSQEEIDKLLMDLESFSQKMET
  SLREPLAKGKNSNFLNSHSQLTGQTLVDLEPKSKVSSPIEKVSPSCLTRIIETNGHKIEEEDRALLLRILESIED
  FAQELVECKSSRGSLSQEKEMMQILQETLTTSSQANLSVCRSPVGDKAKDTTSAVLIQQTPEVIKIQNKPEKKPG
  TPLPPPATSPSSPRPLSPVPHVNNVVNAPLSINIPRFYFPEGLPDTCSNHEQTLSRIETAFMDIEEQKADIYEMG
  KIAKVCGCPLYWKAPMFRAAGGEKTGFVTAQSFIAMWRKLLNNHHDDASKFICLLAKPNCSSLEQEDFIPLLQDV
  VDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWSGKITSTEIRKSNFLQTLALLEEEEDINQITDYFSYEHF
  YVIYCKFWELDTDHDLYISQADLSRYNDQASSSRIIERIFSGAVTRGKTIQKEGRMSYADFVWFLISEEDKRNPT
  SIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHDLLCQMLDLVKPAVDGKITLRDLKRCRMAHI
  FYDTFFNLEKYLDHEQRDPFAVQKDVENDGPEPSDWDRFAAEEYETLVAEESAQAQFQEGFEDYETDEPASPSEF
  GNKSNKILSASLPEKCGKLQSVDEE

• Structural information:
  • Protein Domains: (758..79-)
    (/note="EF-hand-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
    (972..100-)
    (/note="EF-hand-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00448"-)
  • Interpro: IPR011992  IPR041534  IPR018247  IPR002048  
  • Prosite: PS00018 PS50222
  • PDB: 4I5J 4I5K
  • PDBsum: 4I5J 4I5K
  • DIP: 29397
  • STRING: ENSP00000264977
• Other Databases: GeneCards:  PPP2R3A  Malacards:  PPP2R3A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000159	protein phosphatase type 2A complex	IBA	cellular component
GO:0019888	protein phosphatase regulator activity	IBA	molecular function
GO:0006470	protein dephosphorylation	IBA	biological process
GO:0000159	protein phosphatase type 2A complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0019888	protein phosphatase regulator activity	TAS	molecular function
GO:0061053	somite development	ISS	biological process
GO:0043666	regulation of phosphoprotein phosphatase activity	IEA	biological process
GO:0043666	regulation of phosphoprotein phosphatase activity	IEA	biological process
GO:0006470	protein dephosphorylation	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0000159	protein phosphatase type 2A complex	ISS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa05165	Human papillomavirus infection
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04728	Dopaminergic synapse
hsa04071	Sphingolipid signaling pathway
hsa04152	AMPK signaling pathway
hsa03015	mRNA surveillance pathway

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881