• Gene id: 55192

Gene Summary

• Gene Symbol: DNAJC17   Gene   UCSC   Ensembl
• Gene name: DnaJ heat shock protein family (Hsp40) member C17
• Alternate names: dnaJ homolog subfamily C member 17, DnaJ (Hsp40) homolog, subfamily C, member 17,
• Gene location: 15q15.1 (40807476: 40765160)     Exons: 10     NC_000015.10
• OMIM: 616844

Protein Summary

• Protein general information: Q9NVM6  
  • Name: DnaJ homolog subfamily C member 17
  • Length: 304  
  • Mass: 34687
• Sequence:

  MAVTKELLQMDLYALLGIEEKAADKEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQALEVLTDAAARAAYDKV
  RKAKKQAAERTQKLDEKRKKVKLDLEARERQAQAQESEEEEESRSTRTLEQEIERLREEGSRQLEEQQRLIREQI
  RQERDQRLRGKAENTEGQGTPKLKLKWKCKKEDESKGGYSKDVLLRLLQKYGEVLNLVLSSKKPGTAVVEFATVK
  AAELAVQNEVGLVDNPLKISWLEGQPQDAVGRSHSGLSKGSVLSERDYESLVMMRMRQAAERQQLIARMQQEDQE
  GPPT

• Structural information:
  • Protein Domains: (11..7-)
    (/note="J-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00286-)
    (178..24-)
    (/note="RRM"-)
  • Interpro: IPR001623  IPR034254  IPR036869  IPR012677  IPR035979   IPR000504  
  • Prosite: PS50076
  • CDD: cd06257 cd12429
  • PDB: 2D9O
  • PDBsum: 2D9O
  • STRING: ENSP00000220496
• Other Databases: GeneCards:  DNAJC17  Malacards:  DNAJC17

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:1901998	toxin transport	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0000122	negative regulation of transcription by RNA polymerase II	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq