• Gene id: 55180

Gene Summary

• Gene Symbol: LINS1   Gene   UCSC   Ensembl
• Aliases: LINS, MRT27, WINS1
• Gene name: lines homolog 1
• Alternate names: protein Lines homolog 1, WINS1 protein with Drosophila Lines (Lin) homologous domain, mental retardation, non-syndromic, autosomal recessive, 27, truncated LINS1, wnt-signaling molecule Lines homolog 1,
• Gene location: 15q26.3 (100603031: 100566913)     Exons: 10     NC_000015.10
• Gene summary(Entrez): The Drosophila segment polarity gene lin encodes a protein, lines, which plays important roles in development of the epidermis and hindgut. This gene encodes a protein containing a lines-like domain. This gene is located on chromosome 15 and clustered wit
• OMIM: 610350

Protein Summary

• Protein general information: Q8NG48  
  • Name: Protein Lines homolog 1 (Wnt signaling molecule Lines homolog 1)
  • Length: 757  
  • Mass: 85857
  • Tissue specificity: Expressed in adult testis, prostate, prostate, spleen, thymus, skeletal muscle, fetal kidney and brain. {ECO
• Sequence:

  MKVFCEVLEELYKKVLLGATLENDSHDYIFYLNPAVSDQDCSTATSLEWANTCGIQGRHQPISVGVAPIAVAPVC
  LKTNSQMSGSREVMLLQLTVIKVMTTRILSVKTEFHAKEQYRDVIKILLESAKVDSKLICMFQNSDKLLSHMAAQ
  CLALLLYFQLREKITLSNSWIAFCQKNLSEYSESNKAIYCLWTLTAIIKEIFKDSCSQKTEILKQFLTHFDTIFE
  VFYNSLFSQHFENCRDTSKIVNILMCFLDLLELLIASRIHLKLHFTCQRILFLKPSCMLEVITWPIQAFVKRKVI
  IFLKKCLLCKVGEDLCRGSVPALMPPDHHVAVDMLALANAVLQAVNSGLLKTLSVYEKHSFFGGDEVQPECELIT
  SPDHVILRAASLVIMKSLEIKFQNYSSASEVKVDLQRFMSELLTFLKPHLQPSLQLHNPCKWLSRVFIEQDDDML
  EAAKASLGIYLTLTRGCEATESLTQGKEMWDHHTHENGYNPHCIFLFFLKNIGFDSTVLLDFLISSETCFLEYFV
  RYLKLLQKDWDNFFTICNNFDATESKYDISICGCVPSLVQDQSSNQTIPHRLTAPHSHRDVCARHSWASDAPSEP
  LKAVMSKGAHTMCASSLSSPRASQSLVDYDSSDDSDVESTEQCLANSKQTSLHQQATKEIQDAAGTSRDKKEFSL
  EPPSRPLVLKEFDTAFSFDCEVAPNDVVSEVGIFYRIVKCFQELQDAICRLQKKNLFPYNPTALLKLLKYIEVIS
  NKTMNTL

• Structural information:
  • Interpro: IPR029415  IPR032794  IPR024875  
  • STRING: ENSP00000318423
• Other Databases: GeneCards:  LINS1  Malacards:  LINS1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0050890	cognition	IMP	biological process

Diseases

Associated diseases	References
Autosomal recessive mental retardation	KEGG:H00768
Autosomal recessive mental retardation	KEGG:H00768
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Male factor infertility	MIK: 29961538
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881