• Gene id: 55133

Gene Summary

• Gene Symbol: SRBD1   Gene   UCSC   Ensembl
• Gene name: S1 RNA binding domain 1
• Alternate names: S1 RNA-binding domain-containing protein 1, H_NH0576F01.1, WUGSC:H_NH0576F01.1,
• Gene location: 2p21 (45611293: 45388679)     Exons: 23     NC_000002.12

Protein Summary

• Protein general information: Q8N5C6  
  • Name: S1 RNA binding domain containing protein 1
  • Length: 995  
  • Mass: 111776
• Sequence:

  MSSLPRRAKVQVQDVVLKDEFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESKPKRMPRVKKNAPQIS
  DGSEVVVVKEELNSSVAIADTALEDRKNKLDTVQTLKTAKTKQKCAAQPHTVRRTKKLKVEEETSKASNLEGESN
  SSETPSTSTVWGGTCKKEENDDDFTFGQSALKKIKTETYPQGQPVKFPANANSTKEEVEMNWDMVQVLSERTNIE
  PWVCANIIRLFNDDNTIPFIIRYRKELINNLDADSLREVQQTLEELRAVAKKVHSTIQKIKKEGKMSECLLKAML
  NCKTFEELEHVSAPYKTGSKGTKAQRARQLGLEGAARALLEKPGELSLLSYIRPDVKGLSTLQDIEIGVQHILAD
  MIAKDKDTLDFIRNLCQKRHVCIQSSLAKVSSKKVNEKDVDKFLLYQHFSCNIRNIHHHQILAINRGENLKVLTV
  KVNISDGVKDEFCRWCIQNRWRPRSFARPELMKILYNSLNDSFKRLIYPLLCREFRAKLTSDAEKESVMMFGRNL
  RQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKTLLLNFNCSTVVIGNGTA
  CRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDPNLRSAVSIARRVQDPLAELVKIEPK
  HIGVGMYQHDVSQTLLKATLDSVVEECVSFVGVDINICSEVLLRHIAGLNANRAKNIIEWREKNGPFINREQLKK
  VKGLGPKSFQQCAGFIRINQDYIRTFCSQQTETSGQIQGVAVTSSADVEVTNEKQGKKKSKTAVNVLLKPNPLDQ
  TCIHPESYDIAMRFLSSIGGTLYEVGKPEMQQKINSFLEKEGMEKIAERLQTTVHTLQVIIDGLSQPESFDFRTD
  FDKPDFKRSIVCLEDLQIGTVLTGKVENATLFGIFVDIGVGKSGLIPIRNVTEAKLSKTKKRRSLGLGPGERVEV
  QVLNIDIPRSRITLDLIRVL

• Structural information:
  • Protein Domains: (919..99-)
    (/note="S1-motif)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00180"-)
  • Interpro: IPR041692  IPR012340  IPR012337  IPR010994  IPR022967   IPR003029  IPR023323  IPR023319  IPR018974  IPR032639  IPR006641  IPR037027  
  • Prosite: PS50126
  • STRING: ENSP00000263736
• Other Databases: GeneCards:  SRBD1  Malacards:  SRBD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0006412	translation	IBA	biological process
GO:0003729	mRNA binding	IBA	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0006139	nucleobase-containing compound metabolic process	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq