• Gene id: 55076

Gene Summary

• Gene Symbol: TMEM45A   Gene   UCSC   Ensembl
• Aliases: DERP7, DNAPTP4
• Gene name: transmembrane protein 45A
• Alternate names: transmembrane protein 45A, DNA polymerase-transactivated protein 4, dermal papilla derived protein 7,
• Gene location: 3q12.2 (100492618: 100577445)     Exons: 10     NC_000003.12
• OMIM: 616928

Protein Summary

• Protein general information: Q9NWC5  
  • Name: Transmembrane protein 45A (DNA polymerase transactivated protein 4) (Dermal papilla derived protein 7)
  • Length: 275  
  • Mass: 31680
• Sequence:

  MGNFRGHALPGTFFFIIGLWWCTKSILKYICKKQKRTCYLGSKTLFYRLEILEGITIVGMALTGMAGEQFIPGGP
  HLMLYDYKQGHWNQLLGWHHFTMYFFFGLLGVADILCFTISSLPVSLTKLMLSNALFVEAFIFYNHTHGREMLDI
  FVHQLLVLVVFLTGLVAFLEFLVRNNVLLELLRSSLILLQGSWFFQIGFVLYPPSGGPAWDLMDHENILFLTICF
  CWHYAVTIVIVGMNYAFITWLVKSRLKRLCSSEVGLLKNAEREQESEEEM

• Structural information:
  • Interpro: IPR006904  IPR042127  
  • STRING: ENSP00000319009
• Other Databases: GeneCards:  TMEM45A  Malacards:  TMEM45A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)