• Gene id: 55063

Gene Summary

• Gene Symbol: ZCWPW1   Gene   UCSC   Ensembl
• Aliases: ZCW1
• Gene name: zinc finger CW-type and PWWP domain containing 1
• Alternate names: zinc finger CW-type PWWP domain protein 1, zinc finger CW-type and PWWP domain 1, zinc finger, CW-type with PWWP domain 1,
• Gene location: 7q22.1 (100429995: 100400815)     Exons: 19     NC_000007.14

Protein Summary

• Protein general information: Q9H0M4  
  • Name: Zinc finger CW type PWWP domain protein 1
  • Length: 648  
  • Mass: 72007
• Sequence:

  MMTTLQNKEECGKGPKRIFAPPAQKSYSLLPCSPNSPKEETPGISSPETEARISLPKASLKKKEEKATMKNVPSR
  EQEKKRKAQINKQAEKKEKEKSSLTNAEFEEIVQIVLQKSLQECLGMGSGLDFAETSCAQPVVSTQSDKEPGITA
  SATDTDNANGEEVPHTQEISVSWEGEAAPEIRTSKLGQPDPAPSKKKSNRLTLSKRKKEAHEKVEKTQGGHEHRQ
  EDRLKKTVQDHSQIRDQQKGEISGFGQCLVWVQCSFPNCGKWRRLCGNIDPSVLPDNWSCDQNTDVQYNRCDIPE
  ETWTGLESDVAYASYIPGSIIWAKQYGYPWWPGMIESDPDLGEYFLFTSHLDSLPSKYHVTFFGETVSRAWIPVN
  MLKNFQELSLELSVMKKRRNDCSQKLGVALMMAQEAEQISIQERVNLFGFWSRFNGSNSNGERKDLQLSGLNSPG
  SCLEKKEKEEELEKEEGEKTDPILPIRKRVKIQTQKTKPRGLGGDAGTADGRGRTLQRKIMKRSLGRKSTAPPAP
  RMGRKEGQGNSDSDQPGPKKKFKAPQSKALAASFSEGKEVRTVPKNLGLSACKGACPSSAKEEPRHREPLTQEAG
  SVPLEDEASSDLDLEQLMEDVGRELGQSGELQHSNSDGEDFPVALFGK

• Structural information:
  • Protein Domains: (317..38-)
    (/note="PWWP-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00162"-)
  • Interpro: IPR000313  IPR042778  IPR011124  
  • Prosite: PS50812 PS51050
  • PDB: 2E61 2RR4
  • PDBsum: 2E61 2RR4
  • DIP: 59044
  • STRING: ENSP00000381109
• Other Databases: GeneCards:  ZCWPW1  Malacards:  ZCWPW1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008270	zinc ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function

Diseases

Associated diseases	References
Associated with germ cell meiosis	MIK: 31453335
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R
31453335	Associated with germ cell meiosis				Male infertility