• Gene id: 55028

Gene Summary

• Gene Symbol: C17orf80   Gene   UCSC   Ensembl
• Aliases: HLC-8, MIG3, SPEP1
• Gene name: chromosome 17 open reading frame 80
• Alternate names: uncharacterized protein C17orf80, cell migration-inducing gene 3 protein, human lung cancer oncogene 8 protein, lung cancer-related protein 8, sperm-expressed protein 1,
• Gene location: 17q25.1 (73232432: 73248958)     Exons: 10     NC_000017.11
• OMIM: 0

Protein Summary

• Protein general information: Q9BSJ5  
  • Name: Uncharacterized protein C17orf80 (Cell migration inducing gene 3 protein) (Human lung cancer oncogene 8 protein) (HLC 8)
  • Length: 609  
  • Mass: 67315
• Sequence:

  MSDNPPRMEVCPYCKKPFKRLKSHLPYCKMIGPTIPTDQKVYQSKPATLPRAKKMKGPIKDLIKAKGKELETENE
  ERNSKLVVDKPEQTVKTFPLPAVGLERAATTKADKDIKNPIQPSFKMLKNTKPMTTFQEETKAQFYASEKTSPKR
  ELAKDLPKSGESRCNPSEAGASLLVGSIEPSLSNQDRKYSSTLPNDVQTTSGDLKLDKIDPQRQELLVKLLDVPT
  GDCHISPKNVSDGVKRVRTLLSNERDSKGRDHLSGVPTDVTVTETPEKNTESLILSLKMSSLGKIQVMEKQEKGL
  TLGVETCGSKGNAEKSMSATEKQERTVMSHGCENFNTRDSVTGKESQGERPHLSLFIPRETTYQFHSVSQSSSQS
  LASLATTFLQEKKAEAQNHHCVPDVKALMESPEGQLSLEPKSDSQFQASHTGCQSPLCSAQRHTPQSPFTNHAAA
  AGRKTLRSCMGLEWFPELYPGYLGLGVLPGKPQCWNAMTQKPQLISPQGERLSQVSLLERSSTHIRSLEPPAGLT
  TSNFSLMRLLGAVQKGWIRCNTTIRKSGFGGITMLFTGYFVLCCSWSFRRLKKLCRPLPWKSTVPPCIGVAKTTG
  DCRSKTCLD

• Structural information:
  • Interpro: IPR037694  
  • STRING: ENSP00000351937
• Other Databases: GeneCards:  C17orf80  Malacards:  C17orf80

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0070062	extracellular exosome	HDA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0003674	molecular_function	ND	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R