• Gene id: 54988

Gene Summary

• Gene Symbol: ACSM5   Gene   UCSC   Ensembl
• Gene name: acyl-CoA synthetase medium chain family member 5
• Alternate names: acyl-coenzyme A synthetase ACSM5, mitochondrial,
• Gene location: 16p12.3 (20409533: 20441335)     Exons: 14     NC_000016.10
• OMIM: 614361

Protein Summary

• Protein general information: Q6NUN0  
  • Name: Acyl coenzyme A synthetase ACSM5, mitochondrial (EC 6.2.1.2) (Acyl CoA synthetase medium chain family member 5)
  • Length: 579  
  • Mass: 64760
  • Tissue specificity: Detected in kidney and liver. {ECO
• Sequence:

  MRPWLRHLVLQALRNSRAFCGSHGKPAPLPVPQKIVATWEAISLGRQLVPEYFNFAHDVLDVWSRLEEAGHRPPN
  PAFWWVNGTGAEIKWSFEELGKQSRKAANVLGGACGLQPGDRMMLVLPRLPEWWLVSVACMRTGTVMIPGVTQLT
  EKDLKYRLQASRAKSIITSDSLAPRVDAISAECPSLQTKLLVSDSSRPGWLNFRELLREASTEHNCMRTKSRDPL
  AIYFTSGTTGAPKMVEHSQSSYGLGFVASGRRWVALTESDIFWNTTDTGWVKAAWTLFSAWPNGSCIFVHELPRV
  DAKVILNTLSKFPITTLCCVPTIFRLLVQEDLTRYQFQSLRHCLTGGEALNPDVREKWKHQTGVELYEGYGQSET
  VVICANPKGMKIKSGSMGKASPPYDVQIVDDEGNVLPPGEEGNVAVRIRPTRPFCFFNCYLDNPEKTAASEQGDF
  YITGDRARMDKDGYFWFMGRNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLTPAYS
  SHDPEALTRELQEHVKRVTAPYKYPRKVAFVSELPKTVSGKIQRSKLRSQEWGK

• Structural information:
  • Interpro: IPR025110  IPR020845  IPR000873  IPR042099  
  • Prosite: PS00455
  • STRING: ENSP00000327916
• Other Databases: GeneCards:  ACSM5  Malacards:  ACSM5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0015645	fatty acid ligase activity	IBA	molecular function
GO:0006633	fatty acid biosynthetic process	IBA	biological process
GO:0003996	acyl-CoA ligase activity	IBA	molecular function
GO:0006637	acyl-CoA metabolic process	IBA	biological process
GO:0005759	mitochondrial matrix	IBA	cellular component
GO:0004321	fatty-acyl-CoA synthase activity	IBA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0006629	lipid metabolic process	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0016874	ligase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0047760	butyrate-CoA ligase activity	IEA	molecular function
GO:0005759	mitochondrial matrix	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00650	Butanoate metabolism

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)