• Gene id: 54952

Gene Summary

• Gene Symbol: TRNAU1AP   Gene   UCSC   Ensembl
• Aliases: PRO1902, SECP43, TRSPAP1
• Gene name: tRNA selenocysteine 1 associated protein 1
• Alternate names: tRNA selenocysteine 1-associated protein 1, tRNA selenocysteine associated protein (SECP43), tRNA selenocysteine-associated protein 1,
• Gene location: 1p35.3 (28553016: 28578544)     Exons: 5     NC_000001.11

Protein Summary

• Protein general information: Q9NX07  
  • Name: tRNA selenocysteine 1 associated protein 1 (SECp43) (tRNA selenocysteine associated protein 1)
  • Length: 287  
  • Mass: 32499
• Sequence:

  MAASLWMGDLEPYMDENFISRAFATMGETVMSVKIIRNRLTGIPAGYCFVEFADLATAEKCLHKINGKPLPGATP
  AKRFKLNYATYGKQPDNSPEYSLFVGDLTPDVDDGMLYEFFVKVYPSCRGGKVVLDQTGVSKGYGFVKFTDELEQ
  KRALTECQGAVGLGSKPVRLSVAIPKASRVKPVEYSQMYSYSYNQYYQQYQNYYAQWGYDQNTGSYSYSYPQYGY
  TQSTMQTYEEVGDDALEDPMPQLDVTEANKEFMEQSEELYDALMDCHWQPLDTVSSEIPAMM

• Structural information:
  • Protein Domains: (3..8-)
    (/note="RRM-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00176-)
    (96..17-)
    (/note="RRM-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00176"-)
  • Interpro: IPR012677  IPR035979  IPR000504  IPR034510  IPR040434   IPR041085  
  • Prosite: PS50102
  • CDD: cd12612
  • PDB: 2DHG 2DIV
  • PDBsum: 2DHG 2DIV
  • STRING: ENSP00000362936
• Other Databases: GeneCards:  TRNAU1AP  Malacards:  TRNAU1AP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001514	selenocysteine incorporation	ISS	biological process
GO:0005634	nucleus	ISS	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0000049	tRNA binding	IBA	molecular function
GO:0001514	selenocysteine incorporation	IBA	biological process
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0006412	translation	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0001514	selenocysteine incorporation	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)