• Gene id: 54827

Gene Summary

• Gene Symbol: NXPE4   Gene   UCSC   Ensembl
• Aliases: C11orf33, FAM55D
• Gene name: neurexophilin and PC-esterase domain family member 4
• Alternate names: NXPE family member 4, family with sequence similarity 55, member D, protein FAM55D,
• Gene location: 11q23.2 (114596214: 114570590)     Exons: 8     NC_000011.10

Protein Summary

• Protein general information: Q6UWF7  
  • Name: NXPE family member 4 (Protein FAM55D)
  • Length: 544  
  • Mass: 62263
• Sequence:

  MKISMINYKSLLALLFILASWIIFTVFQNSTKVWSALNLSISLHYWNNSTKSLFPKTPLISLKPLTETELRIKEI
  IEKLDQQIPPRPFTHVNTTTSATHSTATILNPRDTYCRGDQLHILLEVRDHLGRRKQYGGDFLRARMSSPALMAG
  ASGKVTDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGVSALWSARNQGYDRVIFTGQFVNGTSQVHSECGLILNT
  NAELCQYLDNRDQEGFYCVRPQHMPCAALTHMYSKNKKVSYLSKQEKSLFERSNVGVEIMEKFNTISVSKCNKET
  VAMKEKCKFGMTSTIPSGHVWRNTWNPVSCSLATVKMKECLRGKLIYLMGDSTIRQWMEYFKASINTLKSVDLHE
  SGKLQHQLAVDLDRNINIQWQKYCYPLIGSMTYSVKEMEYLTRAIDRTGGEKNTVIVISLGQHFRPFPIDVFIRR
  ALNVHKAIQHLLLRSPDTMVIIKTENIREMYNDAERFSDFHGYIQYLIIKDIFQDLSVSIIDAWDITIAYGTNNV
  HPPQHVVGNQINILLNYIC

• Structural information:
  • Interpro: IPR013783  IPR014756  IPR026845  
  • STRING: ENSP00000364627
• Other Databases: GeneCards:  NXPE4  Malacards:  NXPE4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0003674	molecular_function	ND	molecular function
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R