• Gene id: 54707

Gene Summary

• Gene Symbol: GPN2   Gene   UCSC   Ensembl
• Aliases: ATPBD1B
• Gene name: GPN-loop GTPase 2
• Alternate names: GPN-loop GTPase 2, ATP-binding domain 1 family member B,
• Gene location: 1p36.11 (26890282: 26876131)     Exons: 5     NC_000001.11
• OMIM: 176889

Protein Summary

• Protein general information: Q9H9Y4  
  • Name: GPN loop GTPase 2 (ATP binding domain 1 family member B)
  • Length: 310  
  • Mass: 34561
• Sequence:

  MAGAAPTTAFGQAVIGPPGSGKTTYCLGMSEFLRALGRRVAVVNLDPANEGLPYECAVDVGELVGLGDVMDALRL
  GPNGGLLYCMEYLEANLDWLRAKLDPLRGHYFLFDCPGQVELCTHHGALRSIFSQMAQWDLRLTAVHLVDSHYCT
  DPAKFISVLCTSLATMLHVELPHINLLSKMDLIEHYGKLAFNLDYYTEVLDLSYLLDHLASDPFFRHYRQLNEKL
  VQLIEDYSLVSFIPLNIQDKESIQRVLQAVDKANGYCFRAQEQRSLEAMMSAAMGADFHFSSTLGIQEKYLAPSN
  QSVEQEAMQL

• Structural information:
  • Interpro: IPR004130  IPR030231  IPR027417  
  • STRING: ENSP00000363250
• Other Databases: GeneCards:  GPN2  Malacards:  GPN2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003924	GTPase activity	IBA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005575	cellular_component	ND	cellular component
GO:0008150	biological_process	ND	biological process
GO:0003674	molecular_function	ND	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq