• Gene id: 54674

Gene Summary

• Gene Symbol: LRRN3   Gene   UCSC   Ensembl
• Aliases: FIGLER5, NLRR-3, NLRR3
• Gene name: leucine rich repeat neuronal 3
• Alternate names: leucine-rich repeat neuronal protein 3, fibronectin type III, immunoglobulin and leucine rich repeat domains 5, leucine-rich repeat protein, neuronal 3, neuronal leucine-rich repeat protein 3,
• Gene location: 7q31.1 (76627302: 76609985)     Exons: 7     NC_000007.14

Protein Summary

• Protein general information: Q9H3W5  
  • Name: Leucine rich repeat neuronal protein 3 (Neuronal leucine rich repeat protein 3) (NLRR 3)
  • Length: 708  
  • Mass: 79424
• Sequence:

  MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILL
  LQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHN
  LLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLT
  EIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISI
  DSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCV
  IRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEP
  QPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSL
  NIKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQ
  KNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHSYVRNYLQKPTFALGE
  LYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS

• Structural information:
  • Protein Domains: (23..6-)
    (/note="LRRNT-)
    (368..42-)
    (/note="LRRCT-)
    (421..51-)
    (/note="Ig-like-C2-type)
    (523..61-)
    (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"-)
  • Interpro: IPR000483  IPR003961  IPR036116  IPR007110  IPR036179   IPR013783  IPR013098  IPR003599  IPR003598  IPR001611  IPR003591  IPR032675  IPR000372  
  • Prosite: PS50853 PS50835 PS51450
  • CDD: cd00063
  • STRING: ENSP00000397312
• Other Databases: GeneCards:  LRRN3  Malacards:  LRRN3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0051965	positive regulation of synapse assembly	IEA	biological process
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray