Male Infertility Database

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Gene id

54659

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed

Gene Summary

Gene Symbol

UGT1A3 Gene UCSC Ensembl

Aliases

UDPGT, UDPGT 1-3, UGT-1C, UGT1-03, UGT1.3, UGT1A3S, UGT1C

Gene name

UDP glucuronosyltransferase family 1 member A3

Alternate names

UDP-glucuronosyltransferase 1-3, UDP glucuronosyltransferase 1 family, polypeptide A3, UDP glycosyltransferase 1 family, polypeptide A3, UDP-glucuronosyltransferase 1 family polypeptide A3s, UDP-glucuronosyltransferase 1-C, UDP-glucuronosyltransferase 1A3, UGT1,

Gene location

2q37.1 (233729041: 233773299) Exons: 5 NC_000002.12

Gene summary(Entrez)

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a comp

Protein Summary

Protein general information

P35503

Name: UDP glucuronosyltransferase 1 3 (UDPGT 1 3) (UGT1*3) (UGT1 03) (UGT1.3) (EC 2.4.1.17) (UDP glucuronosyltransferase 1 C) (UGT 1C) (UGT1C) (UDP glucuronosyltransferase 1A3)

Length: 534 Mass: 60338

Tissue specificity: Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 1 but not isoform 2 is expressed in esophagus. {ECO

Sequence

MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIKEENFF
TLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVL
TDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICH
AFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAG
SHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKD
RPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRV
KKAHKSKTH

Structural information

Interpro:	IPR002213 IPR035595
Prosite:	PS00375
STRING:	ENSP00000418532

Other Databases

GeneCards: UGT1A3 Malacards: UGT1A3

Gene ontology

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GO accession	Term name	Evidence code	Go category
GO:0008194	UDP-glycosyltransferase a ctivity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0016021	integral component of mem brane	IEA	cellular component
GO:0016757	transferase activity, tra nsferring glycosyl groups	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0015020	glucuronosyltransferase a ctivity	IEA	molecular function
GO:0015020	glucuronosyltransferase a ctivity	IDA	molecular function
GO:0015020	glucuronosyltransferase a ctivity	IDA	molecular function
GO:0015020	glucuronosyltransferase a ctivity	IDA	molecular function
GO:0001972	retinoic acid binding	IDA	molecular function
GO:0042573	retinoic acid metabolic p rocess	IC	biological process
GO:0052697	xenobiotic glucuronidatio n	IDA	biological process
GO:0052696	flavonoid glucuronidation	IDA	biological process
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular component
GO:0052695	cellular glucuronidation	IDA	biological process
GO:0015020	glucuronosyltransferase a ctivity	IDA	molecular function
GO:0052695	cellular glucuronidation	IDA	biological process
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0015020	glucuronosyltransferase a ctivity	IDA	molecular function
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0019899	enzyme binding	IPI	molecular function

KEGG pathways

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Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00983	Drug metabolism - other enzymes
hsa05204	Chemical carcinogenesis
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450
hsa00830	Retinol metabolism
hsa00140	Steroid hormone biosynthesis
hsa00860	Porphyrin and chlorophyll metabolism
hsa00040	Pentose and glucuronate interconversions
hsa00053	Ascorbate and aldarate metabolism

Diseases

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Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746

PubMed references

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PMID	Condition	Population details	Infertility_type	Associated_genes	Abstract
28606200	Cryptorchi dism	Monozgotic twin s (1 control, I cwith cryptorc hidism)	Male infertility	MeDIP-Seq	Show abstract
28606200	Cryptorchi dism	Monozgotic twin s (1 control, I cwith cryptorc hidism)	Male infertility	MeDIP-Seq	Show abstract
31037746	Spermatoge nic defect s	28 men with az oospermia	Male infertility	Microarray	Show abstract

Male Infertility knowledgebase

A repository with genes crucial for male fertility

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Gene ontology

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KEGG pathways

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Diseases

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PubMed references

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Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

Protein Summary

Gene ontology

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KEGG pathways Expand All | Collapse All

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Diseases Expand All | Collapse All

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PubMed references

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KEGG pathways

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Diseases

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