• Gene id: 54596

Gene Summary

• Gene Symbol: L1TD1   Gene   UCSC   Ensembl
• Aliases: ECAT11
• Gene name: LINE1 type transposase domain containing 1
• Alternate names: LINE-1 type transposase domain-containing protein 1, ES cell-associated protein 11, LINE-1 type transposase domain containing 1,
• Gene location: 1p31.3 (62194848: 62212327)     Exons: 5     NC_000001.11
• OMIM: 606547

Protein Summary

• Protein general information: Q5T7N2  
  • Name: LINE 1 type transposase domain containing protein 1 (ES cell associated protein 11)
  • Length: 865  
  • Mass: 98850
• Sequence:

  MSDVSTSVQSKFARLAKKKENITYMKREQLTETDKDIAPVLDLKCKDVSAIMNKFKVLMEIQDLMFEEMRETLKN
  DLKAVLGGKATIPEVKNSENSSSRTEFQQIINLALQKTGMVGKIEGENSKIGDDNENLTFKLEVNELSGKLDNTN
  EYNSNDGKKLPQGESRSYEVMGSMEETLCNIDDRDGNRNVHLEFTERESRKDGEDEFVKEMREERKFQKLKNKEE
  VLKASREEKVLMDEGAVLTLVADLSSATLDISKQWSNVFNILRENDFEPKFLCEVKLAFKCDGEIKTFSDLQSLR
  KFASQKSSVKELLKDVLPQKEEINQGGRKYGIQEKRDKTLIDSKHRAGEITSDGLSFLFLKEVKVAKPEEMKNLE
  TQEEEFSELEELDEEASGMEDDEDTSGLEEEEEEPSGLEEEEEEEASGLEEDEASGLEEEEEQTSEQDSTFQGHT
  LVDAKHEVEITSDGMETTFIDSVEDSESEEEEEGKSSETGKVKTTSLTEKKASRRQKEIPFSYLVGDSGKKKLVK
  HQVVHKTQEEEETAVPTSQGTGTPCLTLCLASPSKSLEMSHDEHKKHSHTNLSISTGVTKLKKTEEKKHRTLHTE
  ELTSKEADLTEETEENLRSSVINSIREIKEEIGNLKSSHSGVLEIENSVDDLSSRMDILEERIDSLEDQIEEFSK
  DTMQMTKQIISKERQRDIEERSRSCNIRLIGIPEKESYENRAEDIIKEIIDENFAELKKGSSLEIVSACRVPSKI
  DEKRLTPRHILVKFWNSSDKEKIIRASRERREITYQGTRIRLTADLSLDTLDARSKWSNVFKVLLEKGFNPRILY
  PAKMAFDFRGKTKVFLSIEEFRDYVLHMPTLRELLGNNIP

• Structural information:
  • Interpro: IPR042566  IPR035300  IPR004244  IPR042497  
  • PDB: 2LR6 3SOO
  • PDBsum: 2LR6 3SOO
  • STRING: ENSP00000419901
• Other Databases: GeneCards:  L1TD1  Malacards:  L1TD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003727	single-stranded RNA binding	IBA	molecular function
GO:0032197	transposition, RNA-mediated	IBA	biological process
GO:1990904	ribonucleoprotein complex	IBA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Defective human spermatozoa	MIK: 26804237
Male infertility	MIK: 26804237

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
26804237	Defective human spermatozoa			95 (46 Asthenozoospermia patients, 49 age-matched normal controls)	Male infertility	MEST  FAM50B LINE-1 P16 GNAS and H19
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881