• Gene id: 54482

Gene Summary

• Gene Symbol: TRMT13   Gene   UCSC   Ensembl
• Aliases: CCDC76
• Gene name: tRNA methyltransferase 13 homolog
• Alternate names: tRNA:m(4)X modification enzyme TRM13 homolog, coiled-coil domain containing 76, coiled-coil domain-containing protein 76, tRNA [Gm4] methyltransferase, tRNA guanosine-2'-O-methyltransferase TRM13 homolog,
• Gene location: 1p21.2 (100133079: 100150497)     Exons: 11     NC_000001.11

Protein Summary

• Protein general information: Q9NUP7  
  • Name: tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled coil domain containing protein 76)
  • Length: 481  
  • Mass: 54247
• Sequence:

  MATSATSPHAPGFPAEGRCGYYVEKKKRFCRMVVAAGKRFCGEHAGAAEEEDARKRILCPLDPKHTVYEDQLAKH
  LKKCNSREKPKPDFYIQDINAGLRDETEIPEQLVPISSLSEEQLEKLIKKLRKASEGLNSTLKDHIMSHPALHDA
  LNDPKNGDSATKHLKQQASILGNIENLKLLGPRRCFVEFGAGKGKLSHWVDIALKDAEKVHFILVEKVTTRFKVD
  GKHRKKNSVFERLQIDIQHLCLNKIPVLREEKLPVVGIGKHLCGMATDLALRCLVETYAASFEERNEEPLAKRIK
  NDKTEKEIYTLAKEGNEKNVPEKWNPVAGIVIALCCHHRCDWRHYVGKEYFRALGLGAVEFHYFQRMSSWATCGM
  RKTSLETSNSTTKRQDNQNDDSEEHDDGGYRITDDGADCLPGLLSVEEKKKIGHLCKLLIDQGRIQYLQQKGFSP
  ALQYYTDPLVSLENVLLTALPNHSSSPETTA

• Structural information:
  • Interpro: IPR007871  IPR039044  IPR022776  IPR021721  
  • Prosite: PS51800
  • STRING: ENSP00000359160
• Other Databases: GeneCards:  TRMT13  Malacards:  TRMT13

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030488	tRNA methylation	IBA	biological process
GO:0008175	tRNA methyltransferase activity	IBA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0030488	tRNA methylation	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0106050	tRNA 2'-O-methyltransferase activity	IEA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)