• Gene id: 51657

Gene Summary

• Gene Symbol: STYXL1   Gene   UCSC   Ensembl
• Aliases: DUSP24, MK-STYX, MKSTYX
• Gene name: serine/threonine/tyrosine interacting like 1
• Alternate names: serine/threonine/tyrosine-interacting-like protein 1, dual specificity phosphatase 24 (putative), dual specificity phosphatase inhibitor MK-STYX, dual specificity protein phosphatase 24, inactive dual specificity protein phosphatase MK-STYX, map kinase phospha,
• Gene location: 7q11.23 (76049343: 75995819)     Exons: 12     NC_000007.14
• OMIM: 616695

Protein Summary

• Protein general information: Q9Y6J8  
  • Name: Serine/threonine/tyrosine interacting like protein 1 (Dual specificity phosphatase inhibitor MK STYX) (Dual specificity protein phosphatase 24) (Inactive dual specificity protein phosphatase MK STYX) (Map kinase phosphatase like protein MK STYX)
  • Length: 313  
  • Mass: 35818
• Sequence:

  MPGLLLCEPTELYNILNQATKLSRLTDPNYLCLLDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCV
  VYDNNSSTLEILLKDDDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMP
  QELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFL
  RHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTI
  LGDSITNIMDPLY

• Structural information:
  • Protein Domains: (27..13-)
    (/note="Rhodanese-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00173-)
    (160..30-)
    (/note="Tyrosine-protein-phosphatase)
    (/evidence="ECO:0000255"-)
  • Interpro: IPR000340  IPR029021  IPR001763  IPR036873  IPR020422  
  • Prosite: PS50054
  • STRING: ENSP00000248600
• Other Databases: GeneCards:  STYXL1  Malacards:  STYXL1

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R