• Gene id: 51596

Gene Summary

• Gene Symbol: CUTA   Gene   UCSC   Ensembl
• Aliases: ACHAP, C6orf82
• Gene name: cutA divalent cation tolerance homolog
• Alternate names: protein CutA, acetylcholinesterase-associated protein, brain acetylcholinesterase putative membrane anchor, divalent cation tolerant protein CUTA,
• Gene location: 6p21.32 (33418287: 33416441)     Exons: 6     NC_000006.12
• OMIM: 616953

Protein Summary

• Protein general information: O60888  
  • Name: Protein CutA (Acetylcholinesterase associated protein) (Brain acetylcholinesterase putative membrane anchor)
  • Length: 179  
  • Mass: 19116
  • Tissue specificity: Ubiquitous. Widely expressed in brain. {ECO
• Sequence:

  MSGGRAPAVLLGGVASLLLSFVWMPALLPVASRLLLLPRVLLTMASGSPPTQPSPASDSGSGYVPGSVSAAFVTC
  PNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIA
  LPVEQGNFPYLQWVRQVTESVSDSITVLP

• Structural information:
  • Interpro: IPR004323  IPR011322  IPR015867  
  • PDB: 1XK8 2ZFH
  • PDBsum: 1XK8 2ZFH
  • STRING: ENSP00000363624
• Other Databases: GeneCards:  CUTA  Malacards:  CUTA

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005507	copper ion binding	IBA	molecular function
GO:0010038	response to metal ion	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016020	membrane	IDA	cellular component
GO:0008104	protein localization	IDA	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0019899	enzyme binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881