• Gene id: 51496

Gene Summary

• Gene Symbol: CTDSPL2   Gene   UCSC   Ensembl
• Aliases: HSPC058, HSPC129, SCP4
• Gene name: CTD small phosphatase like 2
• Alternate names: CTD small phosphatase-like protein 2, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2, CTDSP-like 2,
• Gene location: 15q15.3-q21.1 (44427328: 44529037)     Exons: 16     NC_000015.10
• OMIM: 602571

Protein Summary

• Protein general information: Q05D32  
  • Name: CTD small phosphatase like protein 2 (CTDSP like 2) (EC 3.1.3. )
  • Length: 466  
  • Mass: 52999
• Sequence:

  MRLRTRKASQQSNQIQTQRTARAKRKYSEVDDSLPSGGEKPSKNETGLLSSIKKFIKGSTPKEERENPSKRSRIE
  RDIDNNLITSTPRAGEKPNKQISRVRRKSQVNGEAGSYEMTNQHVKQNGKLEDNPSSGSPPRTTLLGTIFSPVFN
  FFSPANKNGTSGSDSPGQAVEAEEIVKQLDMEQVDEITTSTTTSTNGAAYSNQAVQVRPSLNNGLEEAEETVNRD
  IPPLTAPVTPDSGYSSAHAEATYEEDWEVFDPYYFIKHVPPLTEEQLNRKPALPLKTRSTPEFSLVLDLDETLVH
  CSLNELEDAALTFPVLFQDVIYQVYVRLRPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVRHRLF
  REHCVCVQGNYIKDLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDNELLKLIPFLEKLVELNEDVR
  PHIRDRFRLHDLLPPD

• Structural information:
  • Protein Domains: (283..44-)
    (/note="FCP1-homology)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00336"-)
  • Interpro: IPR011948  IPR004274  IPR036412  IPR023214  
  • Prosite: PS50969
  • STRING: ENSP00000260327
• Other Databases: GeneCards:  CTDSPL2  Malacards:  CTDSPL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000790	nuclear chromatin	IDA	cellular component
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	IDA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IBA	molecular function
GO:0016791	phosphatase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0046827	positive regulation of protein export from nucleus	IEA	biological process
GO:0006470	protein dephosphorylation	IEA	biological process
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0030514	negative regulation of BMP signaling pathway	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq