• Gene id: 51184

Gene Summary

• Gene Symbol: GPN3   Gene   UCSC   Ensembl
• Aliases: ATPBD1C
• Gene name: GPN-loop GTPase 3
• Alternate names: GPN-loop GTPase 3, ATP-binding domain 1 family member C, protein x 0004,
• Gene location: 12q24.11 (110468720: 110452485)     Exons: 9     NC_000012.12
• OMIM: 0

Protein Summary

• Protein general information: Q9UHW5  
  • Name: GPN loop GTPase 3 (ATP binding domain 1 family member C)
  • Length: 284  
  • Mass: 32761
• Sequence:

  MPRYAQLVMGPAGSGKSTYCATMVQHCEALNRSVQVVNLDPAAEHFNYSVMADIRELIEVDDVMEDDSLRFGPNG
  GLVFCMEYFANNFDWLENCLGHVEDDYILFDCPGQIELYTHLPVMKQLVQQLEQWEFRVCGVFLVDSQFMVESFK
  FISGILAALSAMISLEIPQVNIMTKMDLLSKKAKKEIEKFLDPDMYSLLEDSTSDLRSKKFKKLTKAICGLIDDY
  SMVRFLPYDQSDEESMNIVLQHIDFAIQYGEDLEFKEPKEREDESSSMFDEYFQECQDE

• Structural information:
  • Interpro: IPR004130  IPR030228  IPR027417  
  • STRING: ENSP00000442770
• Other Databases: GeneCards:  GPN3  Malacards:  GPN3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003924	GTPase activity	IBA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0032991	protein-containing complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881