• Gene id: 51133

Gene Summary

• Gene Symbol: KCTD3   Gene   UCSC   Ensembl
• Aliases: NY-REN-45
• Gene name: potassium channel tetramerization domain containing 3
• Alternate names: BTB/POZ domain-containing protein KCTD3, NY-REN-45 antigen, potassium channel tetramerisation domain containing 3, renal carcinoma antigen NY-REN-45,
• Gene location: 1q41 (215567303: 215621806)     Exons: 18     NC_000001.11
• Gene summary(Entrez): This gene encodes a member of the potassium channel tetramerization-domain containing (KCTD) protein family. Members of this protein family regulate the biophysical characteristics of ion channels. In mouse, this protein interacts with hyperpolarization-a
• OMIM: 613272

Protein Summary

• Protein general information: Q9Y597  
  • Name: BTB/POZ domain containing protein KCTD3 (Renal carcinoma antigen NY REN 45)
  • Length: 815  
  • Mass: 88984
  • Tissue specificity: Broadly expressed in normal tissues. {ECO
• Sequence:

  MAGGHCGSFPAAAAGSGEIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPIL
  NFLRTKELDLRGVSINVLRHEAEFYGITPLVRRLLLCEELERSSCGSVLFHGYLPPPGIPSRKINNTVRSADSRN
  GLNSTEGEARGNGTQPVLSGTGEETVRLGFPVDPRKVLIVAGHHNWIVAAYAHFAVCYRIKESSGWQQVFTSPYL
  DWTIERVALNAKVVGGPHGDKDKMVAVASESSIILWSVQDGGSGSEIGVFSLGVPVDALFFIGNQLVATSHTGKV
  GVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPSNDAITALSVYL
  TPKTSVSGNWIEIAYGTSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVT
  RFRGMISTQPGSTPLASFKILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEI
  QAVDCTTISSFTVRECEGSSRMGSRPRRYLFTGHTNGSIQMWDLTTAMDMVNKSEDKDVGGPTEEELLKLLDQCD
  LSTSRCATPNISPATSVVQHSHLRESNSSLQLQHHDTTHEAATYGSMRPYRESPLLARARRTESFHSYRDFQTIN
  LNRNVERAVPENGNLGPIQAEVKGATGECNISERKSPGVEIKSLRELDSGLEVHKIAEGFSESKKRSSEDENENK
  IEFRKKGGFEGGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYSL

• Structural information:
  • Protein Domains: (18..8-)
    (/note="BTB-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00037"-)
  • Interpro: IPR000210  IPR011333  IPR003131  IPR015943  IPR001680   IPR019775  IPR036322  
  • Prosite: PS50097 PS00678
  • STRING: ENSP00000259154
• Other Databases: GeneCards:  KCTD3  Malacards:  KCTD3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005886	plasma membrane	ISS	cellular component
GO:0051260	protein homooligomerization	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881