• Gene id: 51105

Gene Summary

• Gene Symbol: PHF20L1   Gene   UCSC   Ensembl
• Aliases: CGI-72, TDRD20B, URLC1
• Gene name: PHD finger protein 20 like 1
• Alternate names: PHD finger protein 20-like protein 1, tudor domain containing 20B, tudor domain-containing protein PHF20L1, up-regulated in lung cancer 1,
• Gene location: 8q24.22 (132775357: 132848806)     Exons: 8     NC_000008.11

Protein Summary

• Protein general information: A8MW92  
  • Name: PHD finger protein 20 like protein 1
  • Length: 1017  
  • Mass: 115010
• Sequence:

  MSKKPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHRYDEWIYWDSNRLRPLERPALRK
  EGLKDEEDFFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQFYDGVIRCLKRMHIKAMPEDAKGQVKSQHPL
  SWCCPIDPAGSCNQSMGSEDWIALVKAAAAAAAKNKTGSKPRTSANSNKDKDKDERKWFKVPSKKEETSTCIATP
  DVEKKEDLPTSSETFGLHVENVPKMVFPQPESTLSNKRKNNQGNSFQAKRARLNKITGLLASKAVGVDGAEKKED
  YNETAPMLEQAISPKPQSQKKNEADISSSANTQKPALLSSTLSSGKARSKKCKHESGDSSGCIKPPKSPLSPELI
  QVEDLTLVSQLSSSVINKTSPPQPVNPPRPFKHSERRRRSQRLATLPMPDDSVEKVSSPSPATDGKVFSISSQNQ
  QESSVPEVPDVAHLPLEKLGPCLPLDLSRGSEVTAPVASDSSYRNECPRAEKEDTQMLPNPSSKAIADGRGAPAA
  AGISKTEKKVKLEDKSSTAFGKRKEKDKERREKRDKDHYRPKQKKKKKKKKKSKQHDYSDYEDSSLEFLERCSSP
  LTRSSGSSLASRSMFTEKTTTYQYPRAILSVDLSGENLSDVDFLDDSSTESLLLSGDEYNQDFDSTNFEESQDED
  DALNEIVRCICEMDEENGFMIQCEECLCWQHSVCMGLLEESIPEQYICYICRDPPGQRWSAKYRYDKEWLNNGRM
  CGLSFFKENYSHLNAKKIVSTHHLLADVYGVTEVLHGLQLKIGILKNKHHPDLHLWACSGKRKDQDQIIAGVEKK
  IAQDTVNREEKKYVQNHKEPPRLPLKMEGTYITSEHSYQKPQSFGQDCKSLADPGSSDDDDVSSLEEEQEFHMRS
  KNSLQYSAKEHGMPEKNPAEGNTVFVYNDKKGTEDPGDSHLQWQLNLLTHIENVQNEVTSRMDLIEKEVDVLESW
  LDFTGELEPPDPLARLPQLKRHIKQLLIDMGKVQQIATLCSV

• Structural information:
  • Protein Domains: (11..7-)
    (/note="Tudor-1)
    (85..14-)
    (/note="Tudor-2")
  • Interpro: IPR014002  IPR022255  IPR040477  IPR004092  IPR002999   IPR019786  IPR011011  IPR013083  
  • Prosite: PS01359
  • PDB: 2EQM 2EQU 2JTF
  • PDBsum: 2EQM 2EQU 2JTF
  • STRING: ENSP00000378784
• Other Databases: GeneCards:  PHF20L1  Malacards:  PHF20L1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IEA	cellular component
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881