|
Gene id |
51053 |
| Gene Summary Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
GMNN Gene UCSC Ensembl |
|
Aliases |
Gem, MGORS6 |
|
Gene name |
geminin DNA replication inhibitor |
|
Alternate names |
geminin, |
|
Gene location |
6p22.3 (24774936: 24786098) Exons: 9 NC_000005.10
|
|
Gene summary(Entrez) |
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-repli
|
|
OMIM |
602842 |
|
| Associated diseases |
References |
| Leukemia | GAD: 19074885 |
| Cancer (breast) | GAD: 17029205 |
| Mitotic phase of spermatogenesis | MIK: 22898305 |
| Meier-Gorlin syndrome | KEGG: H01889 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Cryptorchidism | MIK: 28606200 |
| Mitotic phase of spermatogenesis | MIK: 22898305 |
| Spermatogenic defects | MIK: 31037746 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 22898305 |
Mitotic ph
ase of spe
rmatogenes
is
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
13 (5 controls,
8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
28 men with az
oospermia
|
Male infertility |
Microarray
|
Show abstract |
|