• Gene id: 50636

Gene Summary

• Gene Symbol: ANO7   Gene   UCSC   Ensembl
• Aliases: D-TMPP, DTMPP, IPCA-5, IPCA5, NGEP, PCANAP5, PCANAP5L, TMEM16G
• Gene name: anoctamin 7
• Alternate names: anoctamin-7, Dresden-transmembrane protein of the prostate, prostate cancer associated protein 5, transmembrane protein 16G,
• Gene location: 2q37.3 (241188550: 241239601)     Exons: 27     NC_000002.12
• Gene summary(Entrez): This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different
• OMIM: 605096

Protein Summary

• Protein general information: Q6IWH7  
  • Name: Anoctamin 7 (Dresden transmembrane protein of the prostate) (D TMPP) (IPCA 5) (New gene expressed in prostate) (Prostate cancer associated protein 5) (Transmembrane protein 16G)
  • Length: 933  
  • Mass: 105532
  • Tissue specificity: Specifically expressed in epithelial cells of the prostate (at protein level). {ECO
• Sequence:

  MRMAATAWAGLQGPPLPTLCPAVRTGLYCRDQAHAERWAMTSETSSGSHCARSRMLRRRAQEEDSTVLIDVSPPE
  AEKRGSYGSTAHASEPGGQQAAACRAGSPAKPRIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRA
  AGLCVDQQDVQDGNTTVHYALLSASWAVLCYYAEDLRLKLPLQELPNQASNWSAGLLAWLGIPNVLLEVVPDVPP
  EYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEILAKTPYGHEKKNLLGIHQLLAEGVLSAAFPLHDGPFKT
  PPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLV
  FSDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAY
  RWDCSDYEDTEERPRPQFAASAPMTAPNPITGEDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIM
  AIVVSRSGNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFIFQFVNFY
  SSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLR
  SKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCE
  YRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNR
  TCRYRAFRDDDGHYSQTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEVL
  FGTNGTKDEQPEGSELSSHWTPFTVPKASQLQQ

• Structural information:
  • Interpro: IPR032394  IPR007632  IPR031296  
  • STRING: ENSP00000274979
• Other Databases: GeneCards:  ANO7  Malacards:  ANO7

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005254	chloride channel activity	IBA	molecular function
GO:0005886	plasma membrane	IBA	cellular component
GO:0055085	transmembrane transport	IBA	biological process
GO:0061588	calcium activated phospholipid scrambling	IBA	biological process
GO:1902476	chloride transmembrane transport	IBA	biological process
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005229	intracellular calcium activated chloride channel activity	IDA	NOT|molecular function
GO:0005229	intracellular calcium activated chloride channel activity	IDA	NOT|molecular function
GO:0061588	calcium activated phospholipid scrambling	IEA	biological process
GO:0046983	protein dimerization activity	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0006869	lipid transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0034220	ion transmembrane transport	TAS	biological process
GO:0061591	calcium activated galactosylceramide scrambling	IEA	biological process
GO:0017128	phospholipid scramblase activity	IEA	molecular function
GO:0061590	calcium activated phosphatidylcholine scrambling	IEA	biological process
GO:0061589	calcium activated phosphatidylserine scrambling	IEA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005229	intracellular calcium activated chloride channel activity	IDA	molecular function
GO:0006821	chloride transport	IDA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq